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acp2 acid phosphatase 2, lysosomal [ Danio rerio (zebrafish) ]

Gene ID: 503759, updated on 28-Oct-2024

Summary

Official Symbol
acp2provided by ZNC
Official Full Name
acid phosphatase 2, lysosomalprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050306-40
See related
Ensembl:ENSDARG00000007244 AllianceGenome:ZFIN:ZDB-GENE-050306-40
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi35e03; wu:fi35e03; zgc:113200
Summary
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. [provided by RefSeq, Dec 2017]
Annotation information
Annotation category: partial on reference assembly
Orthologs
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Genomic context

See acp2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (39360781..39371386)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (39089829..39100369)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene midkine a Neighboring gene cholinergic receptor, muscarinic 4a Neighboring gene autophagy/beclin-1 regulator 1a Neighboring gene solute carrier family 8 member B1 Neighboring gene troponin I type 2b (skeletal, fast), tandem duplicate 2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acid phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in lysosomal lumen IEA
Inferred from Electronic Annotation
more info
 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lysosomal acid phosphatase
NP_001013355.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013337.2NP_001013355.1  lysosomal acid phosphatase precursor

    See identical proteins and their annotated locations for NP_001013355.1

    Status: REVIEWED

    Source sequence(s)
    BC090765, DY547619
    UniProtKB/TrEMBL
    Q5CZP5
    Related
    ENSDARP00000142979.1, ENSDART00000173481.2
    Conserved Domains (1) summary
    cd07061
    Location:22322
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    39360781..39371386
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001357187.1: Suppressed sequence

    Description
    NM_001357187.1: This RefSeq was removed because currently there is insufficient support for stop codon readthrough in this gene.