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PEBP1 phosphatidylethanolamine binding protein 1 [ Homo sapiens (human) ]

Gene ID: 5037, updated on 7-Apr-2024

Summary

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Official Symbol
PEBP1provided by HGNC
Official Full Name
phosphatidylethanolamine binding protein 1provided by HGNC
Primary source
HGNC:HGNC:8630
See related
Ensembl:ENSG00000089220 MIM:604591; AllianceGenome:HGNC:8630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PBP; HCNP; PEBP; RKIP; HCNPpp; PEBP-1; HEL-210; HEL-S-34; HEL-S-96
Summary
This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]
Expression
Broad expression in adrenal (RPKM 735.7), liver (RPKM 426.0) and 23 other tissues See more
Orthologs
mouse all
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Genomic context

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See PEBP1 in Genome Data Viewer
Location:
12q24.23
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (118136124..118145584)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (118123375..118132824)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (118573929..118583389)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene V-set and immunoglobulin domain containing 10 Neighboring gene uncharacterized LOC124903029 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4922 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:118543551-118544266 Neighboring gene Sharpr-MPRA regulatory region 1292 Neighboring gene uncharacterized LOC101928274 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancers GRCh37_chr12:118557876-118558588 and GRCh37_chr12:118558589-118559300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:118560014-118560725 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:118560726-118561438 Neighboring gene Sharpr-MPRA regulatory region 10186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:118564319-118564855 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:118573724-118574224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4923 Neighboring gene MPRA-validated peak1994 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7107 Neighboring gene TAO kinase 3 Neighboring gene Sharpr-MPRA regulatory region 13893 Neighboring gene NANOG hESC enhancer GRCh37_chr12:118666512-118667013 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7108 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7109 Neighboring gene ribosomal protein S2 pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7110 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:118778991-118779218 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4927 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7111 Neighboring gene uncharacterized LOC124903031

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RKIP localizes to the nucleus through a bipartite nuclear localization signal and interaction with importin α to regulate mitotic progression. Argueta CE, et al. J Biol Chem, 2023 Apr. PMID 36805338, Free PMC Article
  2. Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop. Lee J, et al. Proc Natl Acad Sci U S A, 2022 Jun 21. PMID 35696587, Free PMC Article
  3. The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart. Abd Alla J, et al. Cells, 2022 Feb 14. PMID 35203304, Free PMC Article
  4. Clinical significance of raf-1 kinase inhibitor protein in oral squamous cell carcinoma and its role in cell metastasis. Lu MM, et al. Eur Rev Med Pharmacol Sci, 2020 Dec. PMID 33336737
  5. PEBP1 suppresses HIV transcription and induces latency by inactivating MAPK/NF-κB signaling. Yang X, et al. EMBO Rep, 2020 Nov 5. PMID 32924251, Free PMC Article

See all (284) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prognostic significance of RKIP, TGM2, and CMTM4 expression in oral squamous cell carcinoma.
    Title: Prognostic significance of RKIP, TGM2, and CMTM4 expression in oral squamous cell carcinoma.
  2. Clinical Significance of Frequently Down-Regulated Phosphatidylethanolamine-Binding Protein-1 in Gallbladder Cancer.
    Title: Clinical Significance of Frequently Down-Regulated Phosphatidylethanolamine-Binding Protein-1 in Gallbladder Cancer.
  3. Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor.
    Title: Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor.
  4. RKIP localizes to the nucleus through a bipartite nuclear localization signal and interaction with importin alpha to regulate mitotic progression.
    Title: RKIP localizes to the nucleus through a bipartite nuclear localization signal and interaction with importin α to regulate mitotic progression.
  5. RKIP suppresses the influenza A virusinduced airway inflammatory response via the ERK/MAPK pathway.
    Title: RKIP suppresses the influenza A virus‑induced airway inflammatory response via the ERK/MAPK pathway.
  6. Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice.
    Title: Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice.
  7. Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway.
    Title: Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway.
  8. Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop.
    Title: Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop.
  9. RKIP Induction Promotes Tumor Differentiation via SOX2 Degradation in NF2-Deficient Conditions.
    Title: RKIP Induction Promotes Tumor Differentiation via SOX2 Degradation in NF2-Deficient Conditions.
  10. The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart.
    Title: The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart.
Submit: New GeneRIF Correction See all GeneRIFs (192)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Nef nef The yeast two-hybrid screen and the coimmunoprecipitation analysis identify the HIV-1 Nef interacting human protein phosphatidylethanolamine binding protein 1 (PEBP1) in cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding HDA PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatidylethanolamine binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
phosphatidylethanolamine-binding protein 1
Names
Raf kinase inhibitory protein
epididymis luminal protein 210
epididymis secretory protein Li 34
epididymis secretory protein Li 96
hippocampal cholinergic neurostimulating peptide
neuropolypeptide h3
prostatic binding protein
raf kinase inhibitor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002567.4 → NP_002558.1  phosphatidylethanolamine-binding protein 1

    See identical proteins and their annotated locations for NP_002558.1

    Status: REVIEWED

    Source sequence(s)
    BC031102, BF978793, X75252
    Consensus CDS
    CCDS9187.1
    UniProtKB/Swiss-Prot
    B2R4S1, P30086
    UniProtKB/TrEMBL
    D9IAI1
    Related
    ENSP00000261313.2, ENST00000261313.3
    Conserved Domains (1) summary
    cd00866
    Location:23 → 171
    PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    118136124..118145584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    118123375..118132824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30086.3 GenPept UniProtKB/Swiss-Prot:P30086

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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