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bmal1.L basic helix-loop-helix ARNT like 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 503673, updated on 4-Nov-2024

Summary

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Official Symbol
bmal1.L
Official Full Name
basic helix-loop-helix ARNT like 1 L homeolog
Primary source
Xenbase:XB-GENE-17342306
Locus tag
XELAEV_18021786mg
See related
EnsemblRapid:ENSXLAG00005020850 AllianceGenome:Xenbase:XB-GENE-17342306
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
arntl; bmal1; xBmal1; arntl.L
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Predicted to act upstream of or within circadian rhythm and regulation of transcription by RNA polymerase II. Predicted to be located in PML body and cytoplasm. Predicted to be part of aryl hydrocarbon receptor complex and transcription regulator complex. Human ortholog(s) of this gene implicated in alcohol dependence and bipolar disorder. Orthologous to human BMAL1 (basic helix-loop-helix ARNT like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See bmal1.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
20
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (4606526..4634749)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (4682205..4697840)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 L homeolog Neighboring gene uncharacterized LOC108713741 Neighboring gene BTB (POZ) domain containing 10 L homeolog Neighboring gene uncharacterized LOC108713743

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within circadian rhythm IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
part_of aryl hydrocarbon receptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aryl hydrocarbon receptor nuclear translocator-like protein 1-like; uncharacterized protein LOC503673
Names
aryl hydrocarbon receptor nuclear translocator like L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095562.1 → NP_001089031.1  Aryl hydrocarbon receptor nuclear translocator-like protein 1-like

    See identical proteins and their annotated locations for NP_001089031.1

    Status: PROVISIONAL

    Source sequence(s)
    BC077551
    UniProtKB/TrEMBL
    Q5EFE9, Q6DDK7
    Related
    ENSXLAP00005061179.1, ENSXLAT00005062631.1
    Conserved Domains (5) summary
    smart00091
    Location:154 → 213
    PAS; PAS domain
    cd00130
    Location:346 → 441
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00010
    Location:79 → 131
    HLH; Helix-loop-helix DNA-binding domain
    pfam00989
    Location:151 → 258
    PAS; PAS fold
    pfam14598
    Location:344 → 449
    PAS_11; PAS domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    4606526..4634749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041589397.1 → XP_041445331.1  uncharacterized protein LOC503673 isoform X1

    UniProtKB/TrEMBL
    A0A1L8GIH4, A0A974HMM0, Q5EFE9
    Conserved Domains (3) summary
    cd11438
    Location:72 → 135
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam00989
    Location:151 → 258
    PAS; PAS fold
    pfam14598
    Location:344 → 449
    PAS_11; PAS domain

  2. XM_041589398.1 → XP_041445332.1  uncharacterized protein LOC503673 isoform X1

    UniProtKB/TrEMBL
    A0A1L8GIH4, A0A974HMM0, Q5EFE9
    Related
    ENSXLAP00005061195.1, ENSXLAT00005062647.1
    Conserved Domains (3) summary
    cd11438
    Location:72 → 135
    bHLH-PAS_ARNTL_PASD3; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) and similar proteins
    pfam00989
    Location:151 → 258
    PAS; PAS fold
    pfam14598
    Location:344 → 449
    PAS_11; PAS domain
Nucleotide Protein Strain
Heading Accession and Version

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