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Dora Dorado [ Drosophila melanogaster (fruit fly) ]

Gene ID: 50356, updated on 18-Sep-2024

Summary

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Official Symbol
Doraprovided by FlyBase
Official Full Name
Doradoprovided by FlyBase
Primary source
FLYBASE:FBgn0085430
Locus tag
Dmel_CG34401
See related
AllianceGenome:FB:FBgn0085430
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15037; CG17757; CG32542; CG34401; CG7307; CG7317; Dmel\CG34401; dora; pelado; pldo; Zswim8
Old locus tag
CG17757; CG32542; Dmel_CG17757; Dmel_CG32542
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity. Involved in positive regulation of miRNA catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in adult brain cell body rind. Orthologous to human ZSWIM8 (zinc finger SWIM-type containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Dora in Genome Data Viewer
Location:
17F1-17F2; 1-61 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18863950..18884075)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18757983..18778108)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ubiquitin specific protease 39 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fl(2)d-associated complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ago2 protects Drosophila siRNAs and microRNAs from target-directed degradation, even in the absence of 2'-O-methylation. Kingston ER, et al. RNA, 2021 Jun. PMID 33853897, Free PMC Article
  2. Evolutionary and functional analysis of the invariant SWIM domain in the conserved Shu2/SWS1 protein family from Saccharomyces cerevisiae to Homo sapiens. Godin SK, et al. Genetics, 2015 Apr. PMID 25659377, Free PMC Article
  3. The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation. Shi CY, et al. Science, 2020 Dec 18. PMID 33184237, Free PMC Article
  4. The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization. Molina-Pelayo C, et al. Life Sci Alliance, 2022 Aug 8. PMID 35940847, Free PMC Article
  5. Endogenous transcripts direct microRNA degradation in Drosophila, and this targeted degradation is required for proper embryonic development. Kingston ER, et al. Mol Cell, 2022 Oct 20. PMID 36150386, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of miRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in target-directed miRNA degradation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dorado
Names
CG34401-PA
CG34401-PB
CG34401-PC
Dora-PA
Dora-PB
Dora-PC
pelado

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    18863950..18884075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_133108.3 → NP_573336.3  dorado, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573336.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    R9PY27

  2. NM_001370011.1 → NP_001356949.1  dorado, isoform C [Drosophila melanogaster]

    Status: REVIEWED

  3. NM_144236.3 → NP_652493.2  dorado, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652493.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A4D6K2F2, Q95ST9, Q9VWN9, R9PY27
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VWN9.2 Q9VWN9

Gene LinkOut

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