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znf281b zinc finger protein 281b [ Danio rerio (zebrafish) ]

Gene ID: 503523, updated on 12-Sep-2024

Summary

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Official Symbol
znf281bprovided by ZNC
Official Full Name
zinc finger protein 281bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050220-1
See related
Ensembl:ENSDARG00000035910 AllianceGenome:ZFIN:ZDB-GENE-050220-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc47h12; im:7158782; wu:fc47h12; zgc:113026
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in hindbrain; midbrain; neural plate; and neural tube. Orthologous to human ZNF281 (zinc finger protein 281). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See znf281b in Genome Data Viewer
Location:
chromosome: 12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (16087077..16102422)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (16038267..16053612)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885952 Neighboring gene potassium inwardly rectifying channel subfamily J member 19b Neighboring gene mucin 13b, cell surface associated Neighboring gene low density lipoprotein receptor-related protein 2b Neighboring gene MAGUK p55 scaffold protein 3b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Analyses of mRNA structure dynamics identify embryonic gene regulatory programs. Beaudoin JD, et al. Nat Struct Mol Biol, 2018 Aug. PMID 30061596, Free PMC Article
  2. A Toolbox for Efficient Proximity-Dependent Biotinylation in Zebrafish Embryos. Rosenthal SM, et al. Mol Cell Proteomics, 2021. PMID 34332124, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 281b
Names
zinc finger protein 281-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012487.2 → NP_001012505.2  zinc finger protein 281b

    Status: VALIDATED

    Source sequence(s)
    AI793460, BC090180, CT653212, CT726855
    UniProtKB/TrEMBL
    A0A8M1N479, F1QM98, Q5EB02
    Related
    ENSDARP00000120960.1, ENSDART00000141898.2
    Conserved Domains (4) summary
    COG5048
    Location:235 → 286
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:183 → 203
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:181 → 203
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:251 → 276
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    16087077..16102422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358452.3 → XP_017213941.1  zinc finger protein 281b isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z1X7, Q5EB02
Nucleotide Protein
Heading Accession and Version

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