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Arfgap3 ADP-ribosylation factor GTPase activating protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 503165, updated on 28-Oct-2024

Summary

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Official Symbol
Arfgap3provided by RGD
Official Full Name
ADP-ribosylation factor GTPase activating protein 3provided by RGD
Primary source
RGD:1560066
See related
EnsemblRapid:ENSRNOG00000046472 AllianceGenome:RGD:1560066
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in COPI coating of Golgi vesicle; presynaptic endocytosis; and protein secretion. Predicted to be located in Golgi apparatus; cytosol; and presynapse. Predicted to be active in photoreceptor ribbon synapse and presynaptic active zone. Orthologous to human ARFGAP3 (ADP ribosylation factor GTPase activating protein 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Lung (RPKM 108.0), Kidney (RPKM 105.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arfgap3 in Genome Data Viewer
Location:
7q34
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116312996..116359300, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114432873..114479206, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124149665..124198298, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene cytochrome b5 reductase 3 Neighboring gene alpha 1,4-galactosyltransferase Neighboring gene protein kinase C and casein kinase substrate in neurons 2 Neighboring gene uncharacterized LOC120093699

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional characterization of novel human ARFGAP3. Liu X, et al. FEBS Lett, 2001 Feb 9. PMID 11172815
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC116119

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in COPI coating of Golgi vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in presynaptic endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in protein secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in protein secretion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in photoreceptor ribbon synapse ISO
Inferred from Sequence Orthology
more info
  
located_in presynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor GTPase-activating protein 3
Names
ARF GAP 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044273.1 → NP_001037738.1  ADP-ribosylation factor GTPase-activating protein 3

    See identical proteins and their annotated locations for NP_001037738.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099081
    UniProtKB/Swiss-Prot
    Q4KLN7
    UniProtKB/TrEMBL
    A0A0G2K4J0
    Related
    ENSRNOP00000065256.4, ENSRNOT00000074960.4
    Conserved Domains (2) summary
    PLN03114
    Location:1 → 488
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    pfam01412
    Location:11 → 121
    ArfGap; Putative GTPase activating protein for Arf

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    116312996..116359300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079783.2 → XP_038935711.1  ADP-ribosylation factor GTPase-activating protein 3 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K4J0
    Conserved Domains (2) summary
    PLN03114
    Location:1 → 487
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    cd09028
    Location:4 → 123
    ArfGap_ArfGap3; Arf1 GTPase-activating protein 3

  2. XM_063264156.1 → XP_063120226.1  ADP-ribosylation factor GTPase-activating protein 3 isoform X3

  3. XM_063264154.1 → XP_063120224.1  ADP-ribosylation factor GTPase-activating protein 3 isoform X1

  4. XM_039079782.2 → XP_038935710.1  ADP-ribosylation factor GTPase-activating protein 3 isoform X4

    UniProtKB/TrEMBL
    A0A0G2K4J0
    Conserved Domains (2) summary
    PLN03114
    Location:1 → 487
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    cd09028
    Location:4 → 123
    ArfGap_ArfGap3; Arf1 GTPase-activating protein 3

  5. XM_039079784.2 → XP_038935712.1  ADP-ribosylation factor GTPase-activating protein 3 isoform X6

    UniProtKB/TrEMBL
    A0A0G2K4J0
    Conserved Domains (2) summary
    PLN03114
    Location:1 → 486
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    cd09028
    Location:4 → 123
    ArfGap_ArfGap3; Arf1 GTPase-activating protein 3

  6. XM_063264155.1 → XP_063120225.1  ADP-ribosylation factor GTPase-activating protein 3 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KLN7.1 GenPept UniProtKB/Swiss-Prot:Q4KLN7

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