Prosap [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Prosapprovided by FlyBase
Primary source: FLYBASE:FBgn0040752
Locus tag: Dmel_CG30483
See related: AllianceGenome:FB:FBgn0040752
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.149; BcDNA:GH23107; CG13354; CG30483; CG8122; D-ProSAP; Dmel\CG30483; prosap; ProSAP; Shank; shank3
Summary: Predicted to enable ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Involved in several processes, including regulation of signal transduction; subsynaptic reticulum organization; and synaptic assembly at neuromuscular junction. Located in neuromuscular junction; postsynaptic density; and terminal bouton. Is expressed in adult head; adult heart; embryonic/larval nervous system; and embryonic/larval somatic muscle cell. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome; autistic disorder; and schizophrenia 15. Orthologous to several human genes including SHANK1 (SH3 and multiple ankyrin repeat domains 1) and SHANK3 (SH3 and multiple ankyrin repeat domains 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 50D3-50E1; 2-68 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (14060456..14140902, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9947961..10028407, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling.
Title: SHANK2 is a frequently amplified oncogene with evolutionarily conserved roles in regulating Hippo signaling.
In addition to its conventional postsynaptic function, Shank also acts presynaptically in synapse development in the brain.
Title: A Presynaptic Function of Shank Protein in Drosophila.
We created the first animal model lacking all Shank proteins and used the Drosophila neuromuscular junction, a model glutamatergic synapse, to characterize the role of Shank at synapses. We identified a novel function of Shank in synapse maturation via regulation of Wnt signaling in the postsynaptic cell.
Title: Shank Modulates Postsynaptic Wnt Signaling to Regulate Synaptic Development.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c14108782-14101790 mobile_element_type = transposon:HMS-Beagle{}824
Loc: c14109582-14093490 mobile_element_type = transposon:roo{}1707

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables synaptic receptor adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables synaptic receptor adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in postsynaptic density assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in subsynaptic reticulum organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prosap

Names: CG30483-PA; CG30483-PC; CG30483-PD; CG30483-PE; Prosap-PA; Prosap-PC; Prosap-PD; Prosap-PE; shank

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

14060456..14140902 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259386.2 → NP_001246315.2 prosap, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246315.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7Z0, F0JAG9

Conserved Domains (6) summary

cd00204
Location:153 → 279

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd00992
Location:641 → 733

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12796
Location:128 → 222

Ank_2; Ankyrin repeats (3 copies)

pfam16511
Location:20 → 103

FERM_f0; N-terminal or F0 domain of Talin-head FERM

sd00045
Location:191 → 222

ANK; ANK repeat [structural motif]

cl17036
Location:467 → 521

SH3; Src Homology 3 domain superfamily
NM_001299474.1 → NP_001286403.1 prosap, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286403.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LF25, F0JAG9

Conserved Domains (6) summary

cd00204
Location:153 → 279

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd00992
Location:495 → 587

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12796
Location:128 → 222

Ank_2; Ankyrin repeats (3 copies)

pfam16511
Location:20 → 103

FERM_f0; N-terminal or F0 domain of Talin-head FERM

sd00045
Location:191 → 222

ANK; ANK repeat [structural motif]

cl17036
Location:321 → 375

SH3; Src Homology 3 domain superfamily
NM_001299473.1 → NP_001286402.1 prosap, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286402.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LFA9, F0JAG9

Conserved Domains (6) summary

cd00204
Location:186 → 312

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd00992
Location:560 → 652

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12796
Location:196 → 322

Ank_2; Ankyrin repeats (3 copies)

pfam16511
Location:20 → 103

FERM_f0; N-terminal or F0 domain of Talin-head FERM

sd00045
Location:191 → 222

ANK; ANK repeat [structural motif]

cl17036
Location:386 → 440

SH3; Src Homology 3 domain superfamily
NM_137081.5 → NP_610925.3 prosap, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610925.3

Status: REVIEWED

UniProtKB/TrEMBL

A1Z9K8, B5RJJ3, F0JAG9

Conserved Domains (6) summary

cd00204
Location:186 → 312

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd00992
Location:706 → 798

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam12796
Location:196 → 322

Ank_2; Ankyrin repeats (3 copies)

pfam16511
Location:20 → 103

FERM_f0; N-terminal or F0 domain of Talin-head FERM

sd00045
Location:191 → 222

ANK; ANK repeat [structural motif]

cl17036
Location:532 → 586

SH3; Src Homology 3 domain superfamily