Idi2 isopentenyl-diphosphate delta isomerase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Idi2provided by RGD
Official Full Name: isopentenyl-diphosphate delta isomerase 2provided by RGD
Primary source: RGD:1559783
See related: EnsemblRapid:ENSRNOG00000089517 AllianceGenome:RGD:1559783
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1559783; RGD1562352
Summary: Predicted to enable isopentenyl-diphosphate delta-isomerase activity. Predicted to be involved in isoprenoid biosynthetic process. Predicted to act upstream of or within isopentenyl diphosphate metabolic process and negative regulation of cholesterol biosynthetic process. Predicted to be located in peroxisome. Orthologous to human IDI2 (isopentenyl-diphosphate delta isomerase 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 17q12.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (66022731..66026333, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (61331385..61334987, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (63107152..63107469)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables isopentenyl-diphosphate delta-isomerase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dimethylallyl diphosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within isopentenyl diphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in isoprenoid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cholesterol biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: isopentenyl-diphosphate delta isomerase 2

NP_001178937.1

EC 5.3.3.2

XP_063132785.1

EC 5.3.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001192008.2 → NP_001178937.1 isopentenyl-diphosphate delta isomerase 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6G2W8, D4AEN4

Related

ENSRNOP00000105291.1, ENSRNOT00000170970.1

Conserved Domains (2) summary

COG1443
Location:18 → 222

Idi; Isopentenyldiphosphate isomerase [Lipid transport and metabolism]

cl00447
Location:18 → 227

Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...