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Cenpv centromere protein V [ Rattus norvegicus (Norway rat) ]

Gene ID: 501702, updated on 2-Nov-2024

Summary

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Official Symbol
Cenpvprovided by RGD
Official Full Name
centromere protein Vprovided by RGD
Primary source
RGD:1565681
See related
EnsemblRapid:ENSRNOG00000003086 AllianceGenome:RGD:1565681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Prr6; RGD1565681
Summary
Predicted to enable carbon-sulfur lyase activity and metal ion binding activity. Predicted to be involved in several processes, including centromere complex assembly; pericentric heterochromatin formation; and positive regulation of cytokinesis. Predicted to act upstream of or within ameboidal-type cell migration. Predicted to be located in several cellular components, including microtubule cytoskeleton; midbody; and nucleus. Predicted to be active in kinetochore; nucleus; and spindle midzone. Orthologous to several human genes including CENPV (centromere protein V). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 138.4), Testes (RPKM 108.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cenpv in Genome Data Viewer
Location:
10q23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (47713778..47746800, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (47214479..47228552, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (48846513..48861893, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene zinc finger, SWIM-type containing 7 Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene nuclear receptor co-repressor 1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class L Neighboring gene transmembrane p24 trafficking protein 4, pseudogene 1 Neighboring gene thymosin beta-4-like Neighboring gene small nucleolar RNA SNORA29 Neighboring gene ubiquitin B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CENP-V is required for centromere organization, chromosome alignment and cytokinesis. Tadeu AM, et al. EMBO J, 2008 Oct 8. PMID 18772885, Free PMC Article
  2. Identification of CENP-V as a novel microtubule-associating molecule that activates Src family kinases through SH3 domain interaction. Honda Z, et al. Genes Cells, 2009 Dec. PMID 19930468
  3. Proteomic analysis of the mammalian nuclear pore complex. Cronshaw JM, et al. J Cell Biol, 2002 Sep 2. PMID 12196509, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carbon-sulfur lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ameboidal-type cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in centromere complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in pericentric heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pericentric heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chromosome organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle midzone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle midzone ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centromere protein V
Names
proline rich 6
proline-rich polypeptide 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398871.1 → NP_001385800.1  centromere protein V

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    D4A9A3
    Related
    ENSRNOP00000004127.8, ENSRNOT00000004127.9
    Conserved Domains (1) summary
    COG3791
    Location:122 → 218
    COG3791; Uncharacterized conserved protein [Function unknown]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    47713778..47746800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269676.1 → XP_063125746.1  centromere protein V isoform X3

  2. XM_063269675.1 → XP_063125745.1  centromere protein V isoform X2

  3. XM_039087273.2 → XP_038943201.1  centromere protein V isoform X1

    Conserved Domains (1) summary
    cl01553
    Location:122 → 156
    GFA; Glutathione-dependent formaldehyde-activating enzyme

RNA

  1. XR_005490266.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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