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Macir macrophage immunometabolism regulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 501195, updated on 2-Nov-2024

Summary

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Official Symbol
Macirprovided by RGD
Official Full Name
macrophage immunometabolism regulatorprovided by RGD
Primary source
RGD:1562136
See related
EnsemblRapid:ENSRNOG00000032398 AllianceGenome:RGD:1562136
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562136
Summary
Predicted to be involved in negative regulation of cytokine production involved in inflammatory response; negative regulation of fibroblast migration; and negative regulation of inflammatory response. Predicted to act upstream of or within negative regulation of epithelial cell migration. Predicted to be located in ciliary transition zone and cytoplasm. Orthologous to human MACIR (macrophage immunometabolism regulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 219.5), Muscle (RPKM 139.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Macir in Genome Data Viewer
Location:
9q36
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (105868072..105888128)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (98420760..98440818)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (111327333..111347428)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene diphosphoinositol pentakisphosphate kinase 2 Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene transfer RNA proline (anticodon AGG) 31 Neighboring gene uncharacterized LOC108351978 Neighboring gene uncharacterized LOC134480423

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation. Dorris ER, et al. J Immunol, 2019 Feb 15. PMID 30659109
  2. C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis. Muthana M, et al. Proc Natl Acad Sci U S A, 2015 Sep 15. PMID 26316022, Free PMC Article
  3. An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. Wright KJ, et al. Genes Dev, 2011 Nov 15. PMID 22085962, Free PMC Article
  4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of fibroblast migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytokine production involved in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fibroblast migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of fibroblast migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
macrophage immunometabolism regulator
Names
UNC119-binding protein C5orf30 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109086.1 → NP_001102556.1  macrophage immunometabolism regulator

    See identical proteins and their annotated locations for NP_001102556.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473997
    UniProtKB/TrEMBL
    A6JR86, D3ZPS9
    Related
    ENSRNOP00000041389.3, ENSRNOT00000045749.6
    Conserved Domains (1) summary
    pfam15435
    Location:3 → 201
    UNC119_bdg; UNC119-binding protein C5orf30 homolog

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    105868072..105888128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596608.3 → XP_017452097.1  macrophage immunometabolism regulator isoform X1

    UniProtKB/TrEMBL
    A6JR86, D3ZPS9
    Related
    ENSRNOP00000093274.1, ENSRNOT00000101908.2
    Conserved Domains (1) summary
    pfam15435
    Location:3 → 201
    UNC119_bdg; UNC119-binding protein C5orf30 homolog

  2. XM_039084127.2 → XP_038940055.1  macrophage immunometabolism regulator isoform X1

    UniProtKB/TrEMBL
    A6JR86, D3ZPS9
    Related
    ENSRNOP00000083706.1, ENSRNOT00000101977.2
    Conserved Domains (1) summary
    pfam15435
    Location:3 → 201
    UNC119_bdg; UNC119-binding protein C5orf30 homolog

  3. XM_017596609.3 → XP_017452098.1  macrophage immunometabolism regulator isoform X1

    UniProtKB/TrEMBL
    A6JR86, D3ZPS9
    Related
    ENSRNOP00000110393.1, ENSRNOT00000158770.1
    Conserved Domains (1) summary
    pfam15435
    Location:3 → 201
    UNC119_bdg; UNC119-binding protein C5orf30 homolog
Nucleotide Protein Strain
Heading Accession and Version

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