Lrrc73 leucine rich repeat containing 73 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrrc73provided by RGD
Official Full Name: leucine rich repeat containing 73provided by RGD
Primary source: RGD:1561390
See related: EnsemblRapid:ENSRNOG00000039856 AllianceGenome:RGD:1561390
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: nod3l
Summary: Orthologous to human LRRC73 (leucine rich repeat containing 73). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Brain (RPKM 18.6), Testes (RPKM 17.0) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (22223735..22227867, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (14726157..14730144, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (17111176..17115249, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of Nod3l in the rat pineal gland exhibits a robust daily rhythm, with ~20-fold higher values at night. Expression is controlled by an adrenergic cyclic AMP mechanism.
Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.

Submit: New GeneRIF Correction

General gene information

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General protein information

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Preferred Names: leucine-rich repeat-containing protein 73

Names: NOD3-like protein; uncharacterized protein C6orf154 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024360.2 → NP_001019531.1 leucine-rich repeat-containing protein 73

See identical proteins and their annotated locations for NP_001019531.1

Status: PROVISIONAL

Source sequence(s)

BC128712

UniProtKB/Swiss-Prot

A1A5L6, Q587K4

UniProtKB/TrEMBL

A6JIS4

Related

ENSRNOP00000057899.2, ENSRNOT00000061185.4

Conserved Domains (2) summary

sd00033
Location:58 → 86

LRR_RI; leucine-rich repeat [structural motif]

cl39015
Location:5 → 255

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

22223735..22227867 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008766878.4 → XP_008765100.1 leucine-rich repeat-containing protein 73 isoform X1

Conserved Domains (1) summary

cl39015
Location:11 → 213

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_039084064.1 → XP_038939992.1 leucine-rich repeat-containing protein 73 isoform X2

Conserved Domains (1) summary

cl39015
Location:19 → 132

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
XM_063267579.1 → XP_063123649.1 leucine-rich repeat-containing protein 73 isoform X3