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Layn layilin [ Rattus norvegicus (Norway rat) ]

Gene ID: 500996, updated on 17-Aug-2024

Summary

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Official Symbol
Laynprovided by RGD
Official Full Name
layilinprovided by RGD
Primary source
RGD:1564444
See related
EnsemblRapid:ENSRNOG00000011228 AllianceGenome:RGD:1564444
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1564444
Summary
Predicted to enable hyaluronic acid binding activity. Predicted to be integral component of membrane. Orthologous to human LAYN (layilin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 32.4), Lung (RPKM 17.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q23
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (60261325..60280797, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (51363928..51384748, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55447203..55469420, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene salt-inducible kinase 2 Neighboring gene transfer RNA proline (anticodon AGG) 89 Neighboring gene uncharacterized LOC120094336 Neighboring gene U4 spliceosomal RNA Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34c Neighboring gene microRNA 34b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Layilin, a novel integral membrane protein, is a hyaluronan receptor. Bono P, et al. Mol Biol Cell, 2001 Apr. PMID 11294894, Free PMC Article
  2. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hyaluronic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
layilin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191997.1 → NP_001178926.1  layilin precursor

    See identical proteins and their annotated locations for NP_001178926.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6J4G7
    Related
    ENSRNOP00000050686.6, ENSRNOT00000040162.6
    Conserved Domains (2) summary
    pfam15102
    Location:190 → 324
    TMEM154; TMEM154 protein family
    cl02432
    Location:37 → 185
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    60261325..60280797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766328.4 → XP_008764550.1  layilin isoform X2

    UniProtKB/TrEMBL
    A0A0G2K085, A6J4G7
    Related
    ENSRNOP00000104639.1, ENSRNOT00000165306.1
    Conserved Domains (1) summary
    cl02432
    Location:30 → 178
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  2. XM_039081959.2 → XP_038937887.1  layilin isoform X5

    UniProtKB/TrEMBL
    A6J4G7
    Conserved Domains (1) summary
    cl02432
    Location:30 → 178
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  3. XM_039081958.2 → XP_038937886.1  layilin isoform X4

    UniProtKB/TrEMBL
    A6J4G7
    Conserved Domains (1) summary
    cl02432
    Location:30 → 178
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  4. XM_063265987.1 → XP_063122057.1  layilin isoform X3

    UniProtKB/TrEMBL
    A6J4G7
    Related
    ENSRNOP00000071344.2, ENSRNOT00000088607.3

  5. XM_006243049.5 → XP_006243111.1  layilin isoform X1

    UniProtKB/TrEMBL
    A6J4G7, D3Z895
    Related
    ENSRNOP00000112146.1, ENSRNOT00000156939.1
    Conserved Domains (2) summary
    pfam15102
    Location:183 → 317
    TMEM154; TMEM154 protein family
    cl02432
    Location:30 → 178
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  6. XM_006243052.5 → XP_006243114.1  layilin isoform X6

    Conserved Domains (1) summary
    pfam15102
    Location:113 → 247
    TMEM154; TMEM154 protein family

RNA

  1. XR_010054013.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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