U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ALG12 homolog of asparagine-linked glycosylation 12 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 5007658, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
ALG12
Official Full Name
homolog of asparagine-linked glycosylation 12
Primary source
TAIR:AT1G02145
Locus tag
AT1G02145
See related
Araport:AT1G02145
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
EBS4; EMS-MUTAGENIZED BRI1(BRASSINOSTEROID INSENSITIVE 1) SUPPRESSOR 4; homolog of asparagine-linked glycosylation 12
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ALG12 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
19
Sequence:
Chromosome: 1; NC_003070.9 (404600..408619)

Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene mago nashi family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Cox19 family protein (CHCH motif)

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Role of SBI2/ALG12/EBS4 in the Regulation of Endoplasmic Reticulum-Associated Degradation (ERAD) Studied by a Null Allele. Sun X, et al. Int J Mol Sci, 2022 May 22. PMID 35628619, Free PMC Article
  2. A mutation in Asparagine-Linked Glycosylation 12 (ALG12) leads to receptor misglycosylation and attenuated responses to multiple microbial elicitors. Trempel F, et al. FEBS Lett, 2020 Aug. PMID 32484235
  3. Mutations of an alpha1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in Arabidopsis. Hong Z, et al. Plant Cell, 2009 Dec. PMID 20023196, Free PMC Article
  4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Role of SBI2/ALG12/EBS4 in the Regulation of Endoplasmic Reticulum-Associated Degradation (ERAD) Studied by a Null Allele.
    Title: The Role of SBI2/ALG12/EBS4 in the Regulation of Endoplasmic Reticulum-Associated Degradation (ERAD) Studied by a Null Allele.
  2. A mutation in Asparagine-Linked Glycosylation 12 (ALG12) leads to receptor misglycosylation and attenuated responses to multiple microbial elicitors.
    Title: A mutation in Asparagine-Linked Glycosylation 12 (ALG12) leads to receptor misglycosylation and attenuated responses to multiple microbial elicitors.
  3. EBS4 encodes the Arabidopsis homolog of the yeast ALG12 enzyme. Mutations partially suppress bri1-9 and restore its brassinosteroid sensitivity. [EBS4]
    Title: Mutations of an alpha1,6 mannosyltransferase inhibit endoplasmic reticulum-associated degradation of defective brassinosteroid receptors in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help
NM_001083977.4
NM_001083978.2
NM_001083979.2
NM_001123742.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables alpha-1,6-mannosyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
homolog of asparagine-linked glycosylation 12
NP_001077446.1
  • homolog of asparagine-linked glycosylation 12 (ALG12); FUNCTIONS IN: alpha-1,6-mannosyltransferase activity; INVOLVED IN: ER-associated protein catabolic process, protein amino acid terminal N-glycosylation; LOCATED IN: endomembrane system, intrinsic to endoplasmic reticulum membrane; CONTAINS InterPro DOMAIN/s: Alg9-like mannosyltransferase (InterPro:IPR005599); BEST Arabidopsis thaliana protein match is: Alg9-like mannosyltransferase family (TAIR:AT5G14850.1); Has 794 Blast hits to 784 proteins in 185 species: Archae - 0; Bacteria - 23; Metazoa - 309; Fungi - 268; Plants - 100; Viruses - 0; Other Eukaryotes - 94 (source: NCBI BLink).
NP_001077447.2
  • homolog of asparagine-linked glycosylation 12 (ALG12); FUNCTIONS IN: alpha-1,6-mannosyltransferase activity; INVOLVED IN: ER-associated protein catabolic process, protein amino acid terminal N-glycosylation; LOCATED IN: intrinsic to endoplasmic reticulum membrane; CONTAINS InterPro DOMAIN/s: Alg9-like mannosyltransferase (InterPro:IPR005599); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_001077448.1
  • homolog of asparagine-linked glycosylation 12 (ALG12); FUNCTIONS IN: alpha-1,6-mannosyltransferase activity; INVOLVED IN: ER-associated protein catabolic process, protein amino acid terminal N-glycosylation; LOCATED IN: endomembrane system, intrinsic to endoplasmic reticulum membrane; CONTAINS InterPro DOMAIN/s: Alg9-like mannosyltransferase (InterPro:IPR005599); Has 793 Blast hits to 783 proteins in 185 species: Archae - 0; Bacteria - 23; Metazoa - 309; Fungi - 268; Plants - 100; Viruses - 0; Other Eukaryotes - 93 (source: NCBI BLink).
NP_001117214.1
  • homolog of asparagine-linked glycosylation 12 (ALG12); FUNCTIONS IN: alpha-1,6-mannosyltransferase activity; INVOLVED IN: ER-associated protein catabolic process, protein amino acid terminal N-glycosylation; LOCATED IN: intrinsic to endoplasmic reticulum membrane; CONTAINS InterPro DOMAIN/s: Alg9-like mannosyltransferase (InterPro:IPR005599); BEST Arabidopsis thaliana protein match is: Alg9-like mannosyltransferase family (TAIR:AT1G16900.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003070.9 Reference assembly

    Range
    404600..408619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001123742.1 → NP_001117214.1  homolog of asparagine-linked glycosylation 12 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001117214.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654E865
    Conserved Domains (1) summary
    cl21590
    Location:1 → 329
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  2. NM_001083978.2 → NP_001077447.2  homolog of asparagine-linked glycosylation 12 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077447.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MR93
    Conserved Domains (1) summary
    cl21590
    Location:1 → 215
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  3. NM_001083979.2 → NP_001077448.1  homolog of asparagine-linked glycosylation 12 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077448.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A8MR93, F4HVW9, F4HVX0, Q0WT37, Q1G329, Q1G330
    UniProtKB/TrEMBL
    A0A0K1SB46, A0A178W3M6, A0A384L399, A0A654E865
    Conserved Domains (1) summary
    cl21590
    Location:35 → 373
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  4. NM_001083977.4 → NP_001077446.1  homolog of asparagine-linked glycosylation 12 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001077446.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654E865
    Conserved Domains (1) summary
    cl21590
    Location:35 → 369
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MR93.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.