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Tnfrsf25 TNF receptor superfamily member 25 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500592, updated on 10-Jul-2024

Summary

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Official Symbol
Tnfrsf25provided by RGD
Official Full Name
TNF receptor superfamily member 25provided by RGD
Primary source
RGD:1598206
See related
EnsemblRapid:ENSRNOG00000021814 AllianceGenome:RGD:1598206
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in apoptotic process and signal transduction. Predicted to be active in plasma membrane. Orthologous to human TNFRSF25 (TNF receptor superfamily member 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 35.1), Spleen (RPKM 21.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tnfrsf25 in Genome Data Viewer
Location:
5q36
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (167904377..167909052)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162621669..162626341)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169288419..169293137)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene nucleolar protein 9 Neighboring gene pleckstrin homology and RhoGEF domain containing G5 Neighboring gene espin Neighboring gene hes family bHLH transcription factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Migone TS, et al. Immunity, 2002 Mar. PMID 11911831
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor receptor superfamily member 25
Names
tumor necrosis factor receptor superfamily, member 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137644.1 → NP_001131116.1  tumor necrosis factor receptor superfamily member 25 precursor

    See identical proteins and their annotated locations for NP_001131116.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473968
    UniProtKB/TrEMBL
    A0A8I5ZZ87, A6IUG8, A6IUG9, D4ADP7
    Related
    ENSRNOP00000052331.2, ENSRNOT00000055466.4
    Conserved Domains (2) summary
    cd13420
    Location:37 → 147
    TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
    cl14633
    Location:324 → 400
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    167904377..167909052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239473.5 → XP_006239535.1  tumor necrosis factor receptor superfamily member 25 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZ87, A6IUG9
    Related
    ENSRNOP00000109588.1, ENSRNOT00000149119.1
    Conserved Domains (2) summary
    cd13420
    Location:51 → 161
    TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
    cl14633
    Location:338 → 414
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_006239474.5 → XP_006239536.1  tumor necrosis factor receptor superfamily member 25 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZ87, A6IUG9
    Conserved Domains (2) summary
    cd13420
    Location:51 → 161
    TNFRSF25; tumor necrosis factor receptor superfamily member 25 (TNFRSF25), also known as death receptor 3 (DR3)
    cl14633
    Location:337 → 413
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. XM_039110651.2 → XP_038966579.1  tumor necrosis factor receptor superfamily member 25 isoform X3

    Conserved Domains (2) summary
    cd00185
    Location:54 → 89
    TNFRSF; CRD1 [structural motif]
    cl22855
    Location:51 → 161
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Nucleotide Protein Strain
Heading Accession and Version

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