U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gmeb1 glucocorticoid modulatory element binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500558, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Gmeb1provided by RGD
Official Full Name
glucocorticoid modulatory element binding protein 1provided by RGD
Primary source
RGD:1563208
See related
EnsemblRapid:ENSRNOG00000010910 AllianceGenome:RGD:1563208
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563208
Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; Hsp27 protein binding activity; and identical protein binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human GMEB1 (glucocorticoid modulatory element binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 64.6), Kidney (RPKM 45.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gmeb1 in Genome Data Viewer
Location:
5q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149703035..149746474, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144421151..144462448, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150408075..150449252, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene opioid receptor, delta 1 Neighboring gene YTH N6-methyladenosine RNA binding protein F2 Neighboring gene U11 spliceosomal RNA Neighboring gene TATA-box binding protein associated factor 12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The factor binding to the glucocorticoid modulatory element of the tyrosine aminotransferase gene is a novel and ubiquitous heteromeric complex. Oshima H, et al. J Biol Chem, 1995 Sep 15. PMID 7665613
  2. Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family. Jimenez-Lara AM, et al. FEBS Lett, 2000 Feb 25. PMID 10692587
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables Hsp27 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glucocorticoid modulatory element-binding protein 1
Names
GMEB-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109268.2 → NP_001102738.1  glucocorticoid modulatory element-binding protein 1

    See identical proteins and their annotated locations for NP_001102738.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158640
    UniProtKB/Swiss-Prot
    B0BN09, Q9QUZ8
    Related
    ENSRNOP00000014506.4, ENSRNOT00000014506.8
    Conserved Domains (1) summary
    pfam01342
    Location:80 → 155
    SAND; SAND domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    149703035..149746474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110613.2 → XP_038966541.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B0BN09, Q9QUZ8
    Conserved Domains (1) summary
    pfam01342
    Location:80 → 155
    SAND; SAND domain

  2. XM_063288267.1 → XP_063144337.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B0BN09, Q9QUZ8

  3. XM_039110614.2 → XP_038966542.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B0BN09, Q9QUZ8
    Conserved Domains (1) summary
    pfam01342
    Location:80 → 155
    SAND; SAND domain

  4. XM_063288269.1 → XP_063144339.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B0BN09, Q9QUZ8

  5. XM_063288268.1 → XP_063144338.1  glucocorticoid modulatory element-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B0BN09, Q9QUZ8

  6. XM_039110615.2 → XP_038966543.1  glucocorticoid modulatory element-binding protein 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QUZ8.3 GenPept UniProtKB/Swiss-Prot:Q9QUZ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools