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Epb41l4b erythrocyte membrane protein band 4.1 like 4B [ Rattus norvegicus (Norway rat) ]

Gene ID: 500464, updated on 2-Nov-2024

Summary

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Official Symbol
Epb41l4bprovided by RGD
Official Full Name
erythrocyte membrane protein band 4.1 like 4Bprovided by RGD
Primary source
RGD:1562988
See related
EnsemblRapid:ENSRNOG00000056550 AllianceGenome:RGD:1562988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562988
Summary
Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in several processes, including actomyosin structure organization; positive regulation of keratinocyte migration; and wound healing. Predicted to be located in apical part of cell; cytosol; and plasma membrane. Predicted to be active in cytoskeleton. Orthologous to human EPB41L4B (erythrocyte membrane protein band 4.1 like 4B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 150.1), Kidney (RPKM 95.1) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Epb41l4b in Genome Data Viewer
Location:
5q24
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (76486886..76647752, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (71691706..71852583, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (74030950..74192275, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 245 Neighboring gene microRNA 32 Neighboring gene ferric-chelate reductase 1-like Neighboring gene protein tyrosine phosphatase, non-receptor type 3 Neighboring gene uncharacterized LOC108350978 Neighboring gene uncharacterized LOC134486937

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expressed in high metastatic cells (Ehm2) is a positive regulator of keratinocyte adhesion and motility: The implication for wound healing. Bosanquet DC, et al. J Dermatol Sci, 2013 Aug. PMID 23664528
  2. Lulu2 regulates the circumferential actomyosin tensile system in epithelial cells through p114RhoGEF. Nakajima H, et al. J Cell Biol, 2011 Oct 17. PMID 22006950, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actomyosin structure organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within actomyosin structure organization ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of keratinocyte migration IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
  
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
  
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
band 4.1-like protein 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127565.2 → NP_001121037.1  band 4.1-like protein 4B isoform 2

    See identical proteins and their annotated locations for NP_001121037.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    B2RYE5
    UniProtKB/TrEMBL
    A0A0G2JU16
    Related
    ENSRNOP00000068924.2, ENSRNOT00000088169.3
    Conserved Domains (5) summary
    smart00295
    Location:87 → 277
    B41; Band 4.1 homologues
    cd13186
    Location:273 → 366
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam00373
    Location:170 → 277
    FERM_M; FERM central domain
    pfam08736
    Location:379 → 419
    FA; FERM adjacent (FA)
    pfam09379
    Location:89 → 151
    FERM_N; FERM N-terminal domain

  2. NM_001401792.2 → NP_001388721.1  band 4.1-like protein 4B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6AAH9

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    76486886..76647752 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110572.2 → XP_038966500.1  band 4.1-like protein 4B isoform X2

    UniProtKB/TrEMBL
    A0A0G2K3H4
    Conserved Domains (3) summary
    smart00295
    Location:87 → 277
    B41; Band 4.1 homologues
    cd13186
    Location:273 → 366
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:379 → 420
    FA; FERM adjacent (FA)

  2. XM_039110571.2 → XP_038966499.1  band 4.1-like protein 4B isoform X1

    Related
    ENSRNOP00000072639.3, ENSRNOT00000090366.3
    Conserved Domains (3) summary
    smart00295
    Location:87 → 277
    B41; Band 4.1 homologues
    cd13186
    Location:273 → 366
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:379 → 420
    FA; FERM adjacent (FA)

  3. XM_039110573.2 → XP_038966501.1  band 4.1-like protein 4B isoform X3

    Related
    ENSRNOP00000101921.1, ENSRNOT00000147948.1
    Conserved Domains (3) summary
    smart00295
    Location:87 → 277
    B41; Band 4.1 homologues
    cd13186
    Location:273 → 366
    FERM_C_NBL4_NBL5; FERM domain C-lobe of Novel band 4.1-like protein 4 and 5 (NBL4 and 5)
    pfam08736
    Location:379 → 420
    FA; FERM adjacent (FA)

  4. XM_063288230.1 → XP_063144300.1  band 4.1-like protein 4B isoform X5

  5. XM_063288229.1 → XP_063144299.1  band 4.1-like protein 4B isoform X4

    Related
    ENSRNOP00000088752.2, ENSRNOT00000102034.2

RNA

  1. XR_010066451.1 RNA Sequence

  2. XR_005504513.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RYE5.1 GenPept UniProtKB/Swiss-Prot:B2RYE5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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