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Kbtbd8 kelch repeat and BTB domain containing 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 500262, updated on 2-Nov-2024

Summary

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Official Symbol
Kbtbd8provided by RGD
Official Full Name
kelch repeat and BTB domain containing 8provided by RGD
Primary source
RGD:1563166
See related
EnsemblRapid:ENSRNOG00000013390 AllianceGenome:RGD:1563166
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563166
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in mesenchymal cell differentiation; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein monoubiquitination. Predicted to be located in Golgi apparatus and spindle. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KBTBD8 (kelch repeat and BTB domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 48.4), Brain (RPKM 43.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kbtbd8 in Genome Data Viewer
Location:
4q34
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (129232781..129245608)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (127675967..127688785)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (127164728..127177537)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486618 Neighboring gene proteasome 20S subunit beta 3, pseudogene 2 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 45 Neighboring gene eukaryotic translation elongation factor 1 gamma, pseudogene 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cell-fate determination by ubiquitin-dependent regulation of translation. Werner A, et al. Nature, 2015 Sep 24. PMID 26399832, Free PMC Article
  2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in neural crest cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in neural crest cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in neural crest cell development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neural crest formation IEA
Inferred from Electronic Annotation
more info
  
involved_in neural crest formation ISO
Inferred from Sequence Orthology
more info
  
involved_in neural crest formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein monoubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul3-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kelch repeat and BTB domain-containing protein 8
Names
kelch repeat and BTB (POZ) domain containing 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109250.3 → NP_001102720.2  kelch repeat and BTB domain-containing protein 8

    Status: VALIDATED

    Source sequence(s)
    BC160902, CR467699
    UniProtKB/TrEMBL
    F8WFZ9
    Related
    ENSRNOP00000017889.5, ENSRNOT00000017889.9
    Conserved Domains (4) summary
    PHA03098
    Location:50 → 516
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:330 → 376
    Kelch; KELCH repeat [structural motif]
    cd18274
    Location:27 → 155
    BTB_POZ_KBTBD8; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8)
    cd18483
    Location:147 → 243
    BACK_KBTBD8; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    129232781..129245608
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236932.4 → XP_006236994.1  kelch repeat and BTB domain-containing protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006236994.1

    UniProtKB/Swiss-Prot
    B1H285
    Related
    ENSRNOP00000104815.1, ENSRNOT00000131208.1
    Conserved Domains (4) summary
    PHA03098
    Location:24 → 490
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:304 → 350
    Kelch; KELCH repeat [structural motif]
    cd18274
    Location:1 → 129
    BTB_POZ_KBTBD8; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8)
    cl28903
    Location:121 → 217
    BACK; BACK (BTB and C-terminal Kelch) domain

  2. XM_039108196.2 → XP_038964124.1  kelch repeat and BTB domain-containing protein 8 isoform X1

    UniProtKB/Swiss-Prot
    B1H285
    Conserved Domains (4) summary
    PHA03098
    Location:24 → 490
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:304 → 350
    Kelch; KELCH repeat [structural motif]
    cd18274
    Location:1 → 129
    BTB_POZ_KBTBD8; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8)
    cl28903
    Location:121 → 217
    BACK; BACK (BTB and C-terminal Kelch) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B1H285.1 GenPept UniProtKB/Swiss-Prot:B1H285

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