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Man1b1 mannosidase, alpha, class 1B, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499751, updated on 18-Sep-2024

Summary

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Official Symbol
Man1b1provided by RGD
Official Full Name
mannosidase, alpha, class 1B, member 1provided by RGD
Primary source
RGD:1563595
See related
EnsemblRapid:ENSRNOG00000012559 AllianceGenome:RGD:1563595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ERMan1; RGD1563595
Summary
Predicted to enable mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing; mannose trimming involved in glycoprotein ERAD pathway; and trimming of terminal mannose on B branch. Predicted to be located in cytoplasmic vesicle and endoplasmic reticulum quality control compartment. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MAN1B1 (mannosidase alpha class 1B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 195.1), Adrenal (RPKM 189.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Man1b1 in Genome Data Viewer
Location:
3p13
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28539778..28563155)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8143877..8165007)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2547259..2569051)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 210 Neighboring gene leucine rich repeat containing 26 Neighboring gene glutamate ionotropic receptor NMDA type subunit 1 Neighboring gene dipeptidylpeptidase 7 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. In vitro mannose trimming property of human ER α-1,2 mannosidase I. Aikawa J, et al. Glycoconj J, 2012 Jan. PMID 22160784
  2. Endoplasmic reticulum (ER) mannosidase I is compartmentalized and required for N-glycan trimming to Man5-6GlcNAc2 in glycoprotein ER-associated degradation. Avezov E, et al. Mol Biol Cell, 2008 Jan. PMID 18003979, Free PMC Article
  3. The specificity of the yeast and human class I ER alpha 1,2-mannosidases involved in ER quality control is not as strict previously reported. Herscovics A, et al. Glycobiology, 2002 Apr. PMID 12090241
  4. Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis. Tremblay LO, et al. Glycobiology, 1999 Oct. PMID 10521544
  5. Endoplasmic reticulum-associated degradation-induced dissociation of class II invariant chain complexes containing a glycosylation-deficient form of p41. Sevilla LM, et al. J Immunol, 2004 Aug 15. PMID 15294975

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in mannoprotein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum quality control compartment ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase
Names
ER alpha-1,2-mannosidase
ER mannosidase 1
NP_001102666.1
XP_038961587.1
XP_038961588.1
XP_063140410.1
XP_063140411.1
XP_063140412.1
XP_063140413.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109196.1 → NP_001102666.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

    See identical proteins and their annotated locations for NP_001102666.1

    Status: VALIDATED

    Source sequence(s)
    BC166449
    UniProtKB/Swiss-Prot
    B2GUY0
    UniProtKB/TrEMBL
    A0A8L2Q8I6, A6JT43
    Related
    ENSRNOP00000016846.7, ENSRNOT00000016846.7
    Conserved Domains (1) summary
    pfam01532
    Location:214 → 653
    Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    28539778..28563155
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284340.1 → XP_063140410.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X1

    UniProtKB/TrEMBL
    A0A8I6A224, A0A8L2Q8I6
    Related
    ENSRNOP00000085331.1, ENSRNOT00000119867.2

  2. XM_063284343.1 → XP_063140413.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X3

  3. XM_063284341.1 → XP_063140411.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X2

  4. XM_039105659.2 → XP_038961587.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X2

    Conserved Domains (1) summary
    pfam01532
    Location:76 → 515
    Glyco_hydro_47; Glycosyl hydrolase family 47

  5. XM_063284342.1 → XP_063140412.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X2

  6. XM_039105660.2 → XP_038961588.1  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase isoform X4

    Conserved Domains (1) summary
    pfam01532
    Location:1 → 333
    Glyco_hydro_47; Glycosyl hydrolase family 47
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2GUY0.2 GenPept UniProtKB/Swiss-Prot:B2GUY0

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