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Tprn taperin [ Rattus norvegicus (Norway rat) ]

Gene ID: 499749, updated on 2-Nov-2024

Summary

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Official Symbol
Tprnprovided by RGD
Official Full Name
taperinprovided by RGD
Primary source
RGD:1562935
See related
EnsemblRapid:ENSRNOG00000010896 AllianceGenome:RGD:1562935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity; protein phosphatase 1 binding activity; and protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in auditory receptor cell stereocilium organization; sensory perception of sound; and stereocilium maintenance. Predicted to be located in several cellular components, including microvillus; nucleoplasm; and stereocilium. Predicted to be active in stereocilium base. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 79. Orthologous to human TPRN (taperin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 146.9), Kidney (RPKM 95.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tprn in Genome Data Viewer
Location:
3p13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28474322..28481800)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8076164..8083642)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2480232..2487710)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene NADPH dependent diflavin oxidoreductase 1 Neighboring gene transmembrane protein 203 Neighboring gene SS nuclear autoantigen 1 Neighboring gene anaphase promoting complex subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Progressive hearing loss and degeneration of hair cell stereocilia in taperin gene knockout mice. Chen M, et al. Biochem Biophys Res Commun, 2016 Oct 28. PMID 27693694
  2. Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79. Rehman AU, et al. Am J Hum Genet, 2010 Mar 12. PMID 20170899, Free PMC Article
  3. Mutations in TPRN cause a progressive form of autosomal-recessive nonsyndromic hearing loss. Li Y, et al. Am J Hum Genet, 2010 Mar 12. PMID 20170898, Free PMC Article
  4. GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing. Liu C, et al. Cell Rep, 2018 Oct 30. PMID 30380417, Free PMC Article
  5. Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function. Zhao B, et al. Elife, 2016 Jun 8. PMID 27269051, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
  
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein phosphatase 1 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase 1 binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine/threonine phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine phosphatase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in auditory receptor cell stereocilium organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within auditory receptor cell stereocilium organization ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of sound IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of sound ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stereocilium maintenance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stereocilium maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in stereocilium maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in microvillus ISO
Inferred from Sequence Orthology
more info
  
located_in microvillus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in stereocilium ISO
Inferred from Sequence Orthology
more info
  
located_in stereocilium ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in stereocilium base IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stereocilium base ISO
Inferred from Sequence Orthology
more info
  
located_in stereocilium base ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
taperin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024309.2 → NP_001019480.2  taperin

    See identical proteins and their annotated locations for NP_001019480.2

    Status: VALIDATED

    Source sequence(s)
    BC083928, JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q5XHX2
    Related
    ENSRNOP00000014489.5, ENSRNOT00000014489.7
    Conserved Domains (3) summary
    PHA03247
    Location:103 → 461
    PHA03247; large tegument protein UL36; Provisional
    pfam13914
    Location:507 → 645
    Phostensin; Phostensin PP1-binding and SH3-binding region
    pfam13916
    Location:8 → 89
    Phostensin_N; PP1-regulatory protein, Phostensin N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    28474322..28481800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XHX2.2 GenPept UniProtKB/Swiss-Prot:Q5XHX2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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