Marchf11 membrane associated ring-CH-type finger 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Marchf11provided by RGD
Official Full Name: membrane associated ring-CH-type finger 11provided by RGD
Primary source: RGD:1559945
See related: EnsemblRapid:ENSRNOG00000024461 AllianceGenome:RGD:1559945
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: March11; MARCH-XI; RGD1559945
Summary: Predicted to enable transferase activity and zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be integral component of membrane. Orthologous to human MARCHF11 (membrane associated ring-CH-type finger 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 450.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (78628793..78730164)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (76898330..76999690)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (78825053..78926402)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MARCH-XI acts as a ubiquitin ligase with a role in ubiquitin-mediated protein sorting in the TGN-MVB transport pathway, which may be involved in mammalian spermiogenesis
Title: MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d2rat144 (e-PCR)
- UniSTS:121636

AW528861 (e-PCR)
- UniSTS:246651

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase MARCHF11

Names: E3 ubiquitin-protein ligase MARCH11; RING-type E3 ubiquitin transferase MARCH11; RING-type E3 ubiquitin transferase MARCHF11; membrane-associated RING finger protein 11; membrane-associated RING-CH protein XI; membrane-associated ring finger (C3HC4) 11

NP_001095298.1

EC 2.3.2.27

XP_017446509.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001101828.1 → NP_001095298.1 E3 ubiquitin-protein ligase MARCHF11

Status: VALIDATED

Source sequence(s)

AB048841, AW528861, CK596283

UniProtKB/Swiss-Prot

A6P320

UniProtKB/TrEMBL

F1LSY5

Conserved Domains (1) summary

cd16700
Location:165 → 215

RING_CH-C4HC3_MARCH4_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH4, MARCH9, MARCH11, and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

78628793..78730164

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591020.3 → XP_017446509.1 E3 ubiquitin-protein ligase MARCHF11 isoform X1

UniProtKB/TrEMBL

A0A8I6GB48

Related

ENSRNOP00000083775.1, ENSRNOT00000102916.2

Conserved Domains (1) summary

cd16810
Location:164 → 215

RING_CH-C4HC3_MARCH11; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH11 (MARCH11)