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Fyb1 FYN binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499537, updated on 28-Oct-2024

Summary

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Official Symbol
Fyb1provided by RGD
Official Full Name
FYN binding protein 1provided by RGD
Primary source
RGD:1563421
See related
EnsemblRapid:ENSRNOG00000013886 AllianceGenome:RGD:1563421
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fyb; ADAP; SLAP-130; p120/p130; RGD1563421
Summary
Predicted to enable lipid binding activity. Predicted to be involved in T cell receptor signaling pathway; integrin-mediated signaling pathway; and protein localization to plasma membrane. Predicted to be located in anchoring junction; cytoplasm; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human FYB1 (FYN binding protein 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Thymus (RPKM 139.4), Spleen (RPKM 114.5) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fyb1 in Genome Data Viewer
Location:
2q16
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (57360084..57508609)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (55621585..55781206)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (55834904..55983805)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene DAB adaptor protein 2 Neighboring gene uncharacterized LOC120100732 Neighboring gene uncharacterized LOC120100733 Neighboring gene complement C9 Neighboring gene RPTOR independent companion of MTOR, complex 2 Neighboring gene oncostatin M receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential requirement for adapter proteins Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa and adhesion- and degranulation-promoting adapter protein in FcepsilonRI signaling and mast cell function. Wu JN, et al. J Immunol, 2004 Jun 1. PMID 15153494
  2. Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. Fujii Y, et al. FEBS Lett, 2003 Apr 10. PMID 12681493
  3. RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation. Ménasché G, et al. Mol Cell Biol, 2007 Jun. PMID 17403904, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
NOT acts_upstream_of_or_within mast cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FYN-binding protein 1
Names
FYB-120/130
FYN binding protein (FYB-120/130)
FYN-T-binding protein
FYN-binding protein
SLP-76-associated phosphoprotein
adhesion and degranulation promoting adaptor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109176.1 → NP_001102646.1  FYN-binding protein 1

    See identical proteins and their annotated locations for NP_001102646.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474048
    UniProtKB/TrEMBL
    A6KGF4, A6KGF5
    Related
    ENSRNOP00000018634.7, ENSRNOT00000018634.8
    Conserved Domains (3) summary
    PHA03247
    Location:40 → 416
    PHA03247; large tegument protein UL36; Provisional
    pfam14603
    Location:732 → 820
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:489 → 592
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    57360084..57508609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232019.5 → XP_006232081.1  FYN-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3ZIE4
    UniProtKB/TrEMBL
    A6KGF5
    Related
    ENSRNOP00000101858.1, ENSRNOT00000165112.1
    Conserved Domains (3) summary
    PHA03247
    Location:50 → 426
    PHA03247; large tegument protein UL36; Provisional
    pfam14603
    Location:743 → 830
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:500 → 602
    SH3; Src Homology 3 domain superfamily

  2. XM_039102839.2 → XP_038958767.1  FYN-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6G9A9, A6KGF5
    Related
    ENSRNOP00000083646.1, ENSRNOT00000104137.2
    Conserved Domains (3) summary
    PHA03247
    Location:50 → 426
    PHA03247; large tegument protein UL36; Provisional
    pfam14603
    Location:696 → 784
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:499 → 561
    SH3; Src Homology 3 domain superfamily

  3. XM_008760785.4 → XP_008759007.2  FYN-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    A6KGF5
    Conserved Domains (3) summary
    PHA03247
    Location:50 → 426
    PHA03247; large tegument protein UL36; Provisional
    pfam14603
    Location:738 → 826
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:495 → 598
    SH3; Src Homology 3 domain superfamily

  4. XM_063282350.1 → XP_063138420.1  FYN-binding protein 1 isoform X5

  5. XM_039102837.1 → XP_038958765.1  FYN-binding protein 1 isoform X3

    UniProtKB/TrEMBL
    A6KGF4, A6KGF5
    Conserved Domains (3) summary
    PHA03247
    Location:40 → 416
    PHA03247; large tegument protein UL36; Provisional
    pfam14603
    Location:732 → 820
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:489 → 592
    SH3; Src Homology 3 domain superfamily

  6. XM_039102835.2 → XP_038958763.1  FYN-binding protein 1 isoform X3

    UniProtKB/TrEMBL
    A6KGF4, A6KGF5
    Related
    ENSRNOP00000104499.1, ENSRNOT00000134641.1
    Conserved Domains (3) summary
    PHA03247
    Location:40 → 416
    PHA03247; large tegument protein UL36; Provisional
    pfam14603
    Location:732 → 820
    hSH3; Helically-extended SH3 domain
    cl17036
    Location:489 → 592
    SH3; Src Homology 3 domain superfamily

RNA

  1. XR_010063635.1 RNA Sequence

  2. XR_010063636.1 RNA Sequence

  3. XR_005500334.2 RNA Sequence

  4. XR_010063637.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZIE4.2 GenPept UniProtKB/Swiss-Prot:D3ZIE4

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