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OR1F1 olfactory receptor family 1 subfamily F member 1 [ Homo sapiens (human) ]

Gene ID: 4992, updated on 3-Apr-2024

Summary

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Official Symbol
OR1F1provided by HGNC
Official Full Name
olfactory receptor family 1 subfamily F member 1provided by HGNC
Primary source
HGNC:HGNC:8194
See related
Ensembl:ENSG00000168124 MIM:603232; AllianceGenome:HGNC:8194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OLFMF; OR1F4; OR1F5; OR1F6; OR1F7; OR1F8; OR1F9; OR1F10; OR16-36; OR16-37; OR16-88; OR16-89; OR16-90; OR1F13P; OR3-145; ORL1023
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See OR1F1 in Genome Data Viewer
Location:
16p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3188204..3206556)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3214814..3233547)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3238204..3256506)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7127 Neighboring gene tRNA-Pro (anticodon TGG) 3-4 Neighboring gene tRNA-Pro (anticodon TGG) 3-5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7128 Neighboring gene tRNA-Pro (anticodon AGG) 2-8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7129 Neighboring gene tRNA-Lys (anticodon CTT) 4-1 Neighboring gene tRNA-Pro (anticodon AGG) 1-1 Neighboring gene tRNA-Lys (anticodon CTT) 14-1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3261768-3261996 Neighboring gene olfactory receptor family 1 subfamily F member 2 pseudogene Neighboring gene zinc finger protein 200

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A candidate gene for familial Mediterranean fever. French FMF Consortium. Nat Genet, 1997 Sep. PMID 9288094
  2. A transcriptional Map of the FMF region. Bernot A, et al. Genomics, 1998 Jun 1. PMID 9653642
  3. Distribution of olfactory receptor genes in the human genome. Rouquier S, et al. Nat Genet, 1998 Mar. PMID 9500546
  4. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  5. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • AJ003147.9

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 1F1
Names
olfactory receptor, family 1, subfamily F, member 10
olfactory receptor, family 1, subfamily F, member 13 pseudogene
olfactory receptor, family 1, subfamily F, member 4
olfactory receptor, family 1, subfamily F, member 5
olfactory receptor, family 1, subfamily F, member 6
olfactory receptor, family 1, subfamily F, member 7
olfactory receptor, family 1, subfamily F, member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370639.4 → NP_001357568.2  olfactory receptor 1F1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AJ003147
    UniProtKB/Swiss-Prot
    O15246, O43749, Q6IFL5

  2. NM_001370640.6 → NP_001357569.2  olfactory receptor 1F1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AJ003147
    UniProtKB/Swiss-Prot
    O15246, O43749, Q6IFL5
    Related
    ENSP00000305424.2, ENST00000304646.3

  3. NM_001370641.2 → NP_001357570.1  olfactory receptor 1F1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AJ003147
    Consensus CDS
    CCDS10496.1
    UniProtKB/Swiss-Prot
    O15246, O43749, Q6IFL5
    UniProtKB/TrEMBL
    A0A126GVR9
    Conserved Domains (1) summary
    cd15918
    Location:25 → 294
    7tmA_OR1_7-like; olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. NM_012360.3 → NP_036492.1  olfactory receptor 1F1 isoform 1

    See identical proteins and their annotated locations for NP_036492.1

    Status: VALIDATED

    Source sequence(s)
    AJ003147
    Consensus CDS
    CCDS10496.1
    UniProtKB/Swiss-Prot
    O15246, O43749, Q6IFL5
    UniProtKB/TrEMBL
    A0A126GVR9
    Conserved Domains (1) summary
    cd15918
    Location:25 → 294
    7tmA_OR1_7-like; olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    3188204..3206556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522507.4 → XP_011520809.1  olfactory receptor 1F1 isoform X1

    See identical proteins and their annotated locations for XP_011520809.1

    UniProtKB/Swiss-Prot
    O15246, O43749, Q6IFL5
    UniProtKB/TrEMBL
    A0A126GVR9
    Conserved Domains (1) summary
    cd15918
    Location:25 → 294
    7tmA_OR1_7-like; olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    3214814..3233547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380407.1 → XP_054236382.1  olfactory receptor 1F1 isoform X1

    UniProtKB/Swiss-Prot
    O15246, O43749, Q6IFL5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43749.1 GenPept UniProtKB/Swiss-Prot:O43749

Gene LinkOut

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