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Kctd15 potassium channel tetramerization domain containing 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499129, updated on 2-Nov-2024

Summary

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Official Symbol
Kctd15provided by RGD
Official Full Name
potassium channel tetramerization domain containing 15provided by RGD
Primary source
RGD:1583737
See related
EnsemblRapid:ENSRNOG00000021137 AllianceGenome:RGD:1583737
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human KCTD15 (potassium channel tetramerization domain containing 15). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Uterus (RPKM 54.0), Muscle (RPKM 52.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Kctd15 in Genome Data Viewer
Location:
1q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (96395794..96411502, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (87258658..87271979, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (90506697..90522217, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099792 Neighboring gene uncharacterized LOC100910905 Neighboring gene uncharacterized LOC108349467 Neighboring gene carbohydrate sulfotransferase 8 Neighboring gene uncharacterized LOC134483097 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. Gutierrez-Aguilar R, et al. Obesity (Silver Spring), 2012 Feb. PMID 21779089
  2. The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states. Smaldone G, et al. FEBS Lett, 2016 Jun. PMID 27152988
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD15
Names
potassium channel tetramerisation domain containing 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109141.1 → NP_001102611.1  BTB/POZ domain-containing protein KCTD15

    See identical proteins and their annotated locations for NP_001102611.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473979
    UniProtKB/TrEMBL
    B5DF44, F7FCN2
    Conserved Domains (1) summary
    cd18388
    Location:55 → 153
    BTB_POZ_KCTD15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 15 (KCTD15)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    96395794..96411502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063270937.1 → XP_063127007.1  BTB/POZ domain-containing protein KCTD15 isoform X1

    UniProtKB/TrEMBL
    B5DF44

  2. XM_063270944.1 → XP_063127014.1  BTB/POZ domain-containing protein KCTD15 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLF8

  3. XM_063270943.1 → XP_063127013.1  BTB/POZ domain-containing protein KCTD15 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GLF8
    Related
    ENSRNOP00000075028.3, ENSRNOT00000078598.3

  4. XM_063270942.1 → XP_063127012.1  BTB/POZ domain-containing protein KCTD15 isoform X1

    UniProtKB/TrEMBL
    B5DF44

  5. XM_063270932.1 → XP_063127002.1  BTB/POZ domain-containing protein KCTD15 isoform X1

    UniProtKB/TrEMBL
    B5DF44
    Related
    ENSRNOP00000028698.5, ENSRNOT00000028698.8

  6. XM_063270939.1 → XP_063127009.1  BTB/POZ domain-containing protein KCTD15 isoform X1

    UniProtKB/TrEMBL
    B5DF44

  7. XM_063270941.1 → XP_063127011.1  BTB/POZ domain-containing protein KCTD15 isoform X1

    UniProtKB/TrEMBL
    B5DF44

  8. XM_063270935.1 → XP_063127005.1  BTB/POZ domain-containing protein KCTD15 isoform X1

    UniProtKB/TrEMBL
    B5DF44
Nucleotide Protein Strain
Heading Accession and Version

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