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Themis thymocyte selection associated [ Rattus norvegicus (Norway rat) ]

Gene ID: 498985, updated on 2-Nov-2024

Summary

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Official Symbol
Themisprovided by RGD
Official Full Name
thymocyte selection associatedprovided by RGD
Primary source
RGD:1560849
See related
EnsemblRapid:ENSRNOG00000014979 AllianceGenome:RGD:1560849
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560849
Summary
Predicted to be involved in T cell receptor signaling pathway; negative T cell selection; and positive T cell selection. Predicted to be located in cell-cell junction. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm and nucleus. Used to study inflammatory bowel disease. Orthologous to human THEMIS (thymocyte selection associated). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 654.8) See more
Orthologs
human mouse all
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Genomic context

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See Themis in Genome Data Viewer
Location:
1p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (18251136..18483851, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (16433906..16623889, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (17152973..17378225, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein LEG1 homolog Neighboring gene U6 spliceosomal RNA Neighboring gene aldehyde dehydrogenase 8 family, member A1 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene antagonist of mitotic exit network 1, pseudogene 1 Neighboring gene autophagy related 4B, cysteine peptidase, pseudogene 1 Neighboring gene uncharacterized LOC120098804 Neighboring gene uncharacterized LOC120098806 Neighboring gene protein tyrosine phosphatase, receptor type, K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease. Chabod M, et al. PLoS Genet, 2012 Jan. PMID 22275874, Free PMC Article
  2. Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat. Iwata R, et al. Biomed Res, 2010 Feb. PMID 20203423
  3. Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. Patrick MS, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805304, Free PMC Article
  4. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Johnson AL, et al. Nat Immunol, 2009 Aug. PMID 19597497, Free PMC Article
  5. Themis, a T cell-specific protein important for late thymocyte development. Lesourne R, et al. Nat Immunol, 2009 Aug. PMID 19597498, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat.
    Title: Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative T cell selection ISO
Inferred from Sequence Orthology
more info
  
involved_in positive T cell selection ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein THEMIS; thymocyte selection associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432406.1 → NP_001419335.1  thymocyte selection associated

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A6JPE7, F1M3E4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    18251136..18483851 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017589835.3 → XP_017445324.3  protein THEMIS

    Related
    ENSRNOP00000020102.7, ENSRNOT00000020102.9
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials