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ZBTB21 zinc finger and BTB domain containing 21 [ Homo sapiens (human) ]

Gene ID: 49854, updated on 19-Sep-2024

Summary

Official Symbol
ZBTB21provided by HGNC
Official Full Name
zinc finger and BTB domain containing 21provided by HGNC
Primary source
HGNC:HGNC:13083
See related
Ensembl:ENSG00000173276 MIM:616485; AllianceGenome:HGNC:13083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF295
Summary
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; POZ domain binding activity; and methyl-CpG binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal (RPKM 15.8), gall bladder (RPKM 5.4) and 23 other tissues See more
Orthologs
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Genomic context

See ZBTB21 in Genome Data Viewer
Location:
21q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (41986831..42010360, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (40377057..40400598, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (43406940..43430469, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18485 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:43241376-43242575 Neighboring gene PR/SET domain 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43256373-43257080 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:43274198-43275397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18488 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18489 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13333 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18493 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43318691-43319691 Neighboring gene C2 calcium dependent domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18495 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43364315-43364815 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43370715-43371220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43373099-43373873 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43378985-43379952 Neighboring gene NANOG hESC enhancer GRCh37_chr21:43388567-43389068 Neighboring gene small nucleolar RNA, H/ACA box 91 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:43415728-43415930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13335 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13336 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13337 Neighboring gene ZNF295 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43460101-43460604 Neighboring gene uncharacterized LOC107985502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43461111-43461614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43463997-43464496 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43479981-43480564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43480565-43481148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18502 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43487460-43488014 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43492613-43493114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43493115-43493614 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43495709-43496210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43496211-43496710 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:43501841-43502776 Neighboring gene uromodulin like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43513487-43513992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43523509-43524067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:43524068-43524625 Neighboring gene Sharpr-MPRA regulatory region 15350 Neighboring gene UMODL1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp781N1974

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables POZ domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyl-CpG binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 21
Names
zinc finger protein 295

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098402.2NP_001091872.1  zinc finger and BTB domain-containing protein 21 isoform L

    See identical proteins and their annotated locations for NP_001091872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate exon in the 5' UTR compared to variant 5. Variants 1, 2, and 5 encode the longer isoform (L).
    Source sequence(s)
    AB041014, BP230048
    Consensus CDS
    CCDS13678.1
    UniProtKB/Swiss-Prot
    Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
    Related
    ENSP00000308759.5, ENST00000310826.10
    Conserved Domains (6) summary
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:746773
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:545598
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  2. NM_001098403.2NP_001091873.1  zinc finger and BTB domain-containing protein 21 isoform S

    See identical proteins and their annotated locations for NP_001091873.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an in-frame segment in the coding region compared to variant 5. Variants 3 and 4 encode isoform S, which is shorter than isoform L.
    Source sequence(s)
    AB041015, BP230048
    Consensus CDS
    CCDS42934.1
    UniProtKB/Swiss-Prot
    Q9ULJ3
    Related
    ENSP00000381517.3, ENST00000398505.7
    Conserved Domains (3) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00019
    Location:710730
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
  3. NM_001320729.2NP_001307658.1  zinc finger and BTB domain-containing protein 21 isoform S

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame segment in the coding region compared to variant 1. Variants 3 and 4 encode isoform S, which is shorter than isoform L.
    Source sequence(s)
    AB041015, BC063290, BP230048
    Consensus CDS
    CCDS42934.1
    UniProtKB/Swiss-Prot
    Q9ULJ3
    Conserved Domains (3) summary
    smart00225
    Location:31120
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00019
    Location:710730
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:20120
    BTB; BTB/POZ domain
  4. NM_001320731.2NP_001307660.1  zinc finger and BTB domain-containing protein 21 isoform L

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript. Variants 1, 2, and 5 encode the longer isoform (L).
    Source sequence(s)
    AB041014, AB041015, AJ003669, BC063290, CR933655
    Consensus CDS
    CCDS13678.1
    UniProtKB/Swiss-Prot
    Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
    Related
    ENSP00000381512.1, ENST00000398499.5
    Conserved Domains (6) summary
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:746773
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:545598
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  5. NM_020727.5NP_065778.3  zinc finger and BTB domain-containing protein 21 isoform L

    See identical proteins and their annotated locations for NP_065778.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains two alternate exons in the 5' UTR compared to variant 5. Variants 1, 2, and 5 encode the longer isoform (L).
    Source sequence(s)
    AB041014, BC063290, BP230048
    Consensus CDS
    CCDS13678.1
    UniProtKB/Swiss-Prot
    Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
    Related
    ENSP00000381523.3, ENST00000398511.3
    Conserved Domains (6) summary
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:746773
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:545598
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    41986831..42010360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440793.1XP_047296749.1  zinc finger and BTB domain-containing protein 21 isoform X2

  2. XM_011529588.3XP_011527890.1  zinc finger and BTB domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_011527890.1

    UniProtKB/Swiss-Prot
    Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
    Conserved Domains (6) summary
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:746773
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:545598
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  3. XM_047440788.1XP_047296744.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
  4. XM_047440792.1XP_047296748.1  zinc finger and BTB domain-containing protein 21 isoform X2

  5. XM_017028360.2XP_016883849.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
    Conserved Domains (6) summary
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:746773
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:545598
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  6. XM_047440794.1XP_047296750.1  zinc finger and BTB domain-containing protein 21 isoform X2

  7. XM_047440786.1XP_047296742.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
  8. XM_047440795.1XP_047296751.1  zinc finger and BTB domain-containing protein 21 isoform X2

  9. XM_047440790.1XP_047296746.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
  10. XM_047440787.1XP_047296743.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
  11. XM_047440796.1XP_047296752.1  zinc finger and BTB domain-containing protein 21 isoform X2

  12. XM_047440791.1XP_047296747.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
  13. XM_005261121.4XP_005261178.1  zinc finger and BTB domain-containing protein 21 isoform X1

    See identical proteins and their annotated locations for XP_005261178.1

    UniProtKB/Swiss-Prot
    Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3
    Conserved Domains (6) summary
    sd00017
    Location:548569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:911931
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18209
    Location:12123
    BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
    pfam00096
    Location:670692
    zf-C2H2; Zinc finger, C2H2 type
    pfam18450
    Location:746773
    zf_C2H2_6; Zinc Finger domain
    cd20908
    Location:545598
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  14. XM_047440797.1XP_047296753.1  zinc finger and BTB domain-containing protein 21 isoform X2

  15. XM_047440789.1XP_047296745.1  zinc finger and BTB domain-containing protein 21 isoform X1

    UniProtKB/Swiss-Prot
    Q5R2W1, Q5R2W2, Q6P4R0, Q9ULJ3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    40377057..40400598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324536.1XP_054180511.1  zinc finger and BTB domain-containing protein 21 isoform X2

  2. XM_054324530.1XP_054180505.1  zinc finger and BTB domain-containing protein 21 isoform X1

  3. XM_054324531.1XP_054180506.1  zinc finger and BTB domain-containing protein 21 isoform X1

  4. XM_054324535.1XP_054180510.1  zinc finger and BTB domain-containing protein 21 isoform X2

  5. XM_054324528.1XP_054180503.1  zinc finger and BTB domain-containing protein 21 isoform X1

  6. XM_054324539.1XP_054180514.1  zinc finger and BTB domain-containing protein 21 isoform X2

  7. XM_054324526.1XP_054180501.1  zinc finger and BTB domain-containing protein 21 isoform X1

  8. XM_054324537.1XP_054180512.1  zinc finger and BTB domain-containing protein 21 isoform X2

  9. XM_054324532.1XP_054180507.1  zinc finger and BTB domain-containing protein 21 isoform X1

  10. XM_054324538.1XP_054180513.1  zinc finger and BTB domain-containing protein 21 isoform X2

  11. XM_054324533.1XP_054180508.1  zinc finger and BTB domain-containing protein 21 isoform X1

  12. XM_054324527.1XP_054180502.1  zinc finger and BTB domain-containing protein 21 isoform X1

  13. XM_054324540.1XP_054180515.1  zinc finger and BTB domain-containing protein 21 isoform X2

  14. XM_054324534.1XP_054180509.1  zinc finger and BTB domain-containing protein 21 isoform X1

  15. XM_054324529.1XP_054180504.1  zinc finger and BTB domain-containing protein 21 isoform X1