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Coq2 coenzyme Q2, polyprenyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 498332, updated on 2-Nov-2024

Summary

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Official Symbol
Coq2provided by RGD
Official Full Name
coenzyme Q2, polyprenyltransferaseprovided by RGD
Primary source
RGD:1306722
See related
EnsemblRapid:ENSRNOG00000002194 AllianceGenome:RGD:1306722
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
PHB:PPT; RGD1306722
Summary
Predicted to enable 4-hydroxybenzoate polyprenyltransferase activity. Predicted to be involved in glycerol metabolic process and ubiquinone biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Biomarker of glucose intolerance. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 1. Orthologous to human COQ2 (coenzyme Q2, polyprenyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 227.2), Muscle (RPKM 225.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Coq2 in Genome Data Viewer
Location:
14p22
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (9245777..9265784)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (8941429..8961418)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (10581102..10601093)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352710 Neighboring gene heparanase Neighboring gene peptidylprolyl isomerase D, pseudogene 10 Neighboring gene uncharacterized LOC120096567 Neighboring gene nuclear receptor-binding factor 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats. Sasaki D, et al. Mamm Genome, 2015 Dec. PMID 26296322
  2. The COQ2 genotype predicts the severity of coenzyme Q10 deficiency. Desbats MA, et al. Hum Mol Genet, 2016 Oct 1. PMID 27493029
  3. Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis. López-Martín JM, et al. Hum Mol Genet, 2007 May 1. PMID 17374725, Free PMC Article
  4. A mutation in para-hydroxybenzoate-polyprenyl transferase (COQ2) causes primary coenzyme Q10 deficiency. Quinzii C, et al. Am J Hum Genet, 2006 Feb. PMID 16400613, Free PMC Article
  5. Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ. Forsgren M, et al. Biochem J, 2004 Sep 1. PMID 15153069, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are differentially expressed in obese rats, suggesting that these two genes are candidates for the onset of type 2 diabetes associated with obesity in rats.
    Title: New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124824

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4-hydroxybenzoate polyprenyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4-hydroxybenzoate polyprenyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 4-hydroxybenzoate polyprenyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables 4-hydroxybenzoate polyprenyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables prenyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquinone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
4-hydroxybenzoate polyprenyltransferase, mitochondrial
Names
4-HB polyprenyltransferase
PHB:polyprenyltransferase
coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
coenzyme Q2 homolog, prenyltransferase
para-hydroxybenzoate--polyprenyltransferase, mitochondrial
NP_001037720.1
XP_006250737.1
XP_038948205.1
XP_038948207.1
XP_038948208.1
XP_038948209.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044255.1 → NP_001037720.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001037720.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099827
    UniProtKB/Swiss-Prot
    Q499N4
    UniProtKB/TrEMBL
    A6K5Y9, G3V698
    Related
    ENSRNOP00000002987.4, ENSRNOT00000002987.6
    Conserved Domains (1) summary
    cl00337
    Location:68 → 353
    PT_UbiA; UbiA family of prenyltransferases (PTases)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    9245777..9265784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250675.5 → XP_006250737.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A6K5Y9, G3V698
    Conserved Domains (1) summary
    cl00337
    Location:68 → 290
    PT_UbiA; UbiA family of prenyltransferases (PTases)

  2. XM_039092279.2 → XP_038948207.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00337
    Location:68 → 181
    PT_UbiA; UbiA family of prenyltransferases (PTases)

  3. XM_039092280.2 → XP_038948208.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl00337
    Location:68 → 181
    PT_UbiA; UbiA family of prenyltransferases (PTases)

  4. XM_039092277.2 → XP_038948205.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X2

    Conserved Domains (1) summary
    cl00337
    Location:68 → 211
    PT_UbiA; UbiA family of prenyltransferases (PTases)

  5. XM_039092281.2 → XP_038948209.1  4-hydroxybenzoate polyprenyltransferase, mitochondrial isoform X5

    Conserved Domains (1) summary
    cl00337
    Location:68 → 210
    PT_UbiA; UbiA family of prenyltransferases (PTases)

RNA

  1. XR_005492997.2 RNA Sequence

  2. XR_010057400.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q499N4.1 GenPept UniProtKB/Swiss-Prot:Q499N4

Gene LinkOut

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