U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gjc2 gap junction protein, gamma 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 497913, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Gjc2provided by RGD
Official Full Name
gap junction protein, gamma 2provided by RGD
Primary source
RGD:1562712
See related
EnsemblRapid:ENSRNOG00000038328 AllianceGenome:RGD:1562712
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cx47; Gja12
Summary
Predicted to enable gap junction channel activity involved in cell communication by electrical coupling. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of calcium ion transmembrane transport; and positive regulation of oligodendrocyte progenitor proliferation. Located in several cellular components, including paranode region of axon; perikaryon; and proximal neuron projection. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in hereditary lymphedema IC; hereditary spastic paraplegia 44; hypomyelinating leukodystrophy 2; and lymphedema. Orthologous to human GJC2 (gap junction protein gamma 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Brain (RPKM 54.1), Lung (RPKM 12.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gjc2 in Genome Data Viewer
Location:
10q22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (44462203..44470924, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (43962642..43971358, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (45526740..45535520, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100911111 Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene iron-sulfur cluster assembly factor IBA57 Neighboring gene guanylate kinase 1 Neighboring gene similar to human chromosome 1 open reading frame 35 Neighboring gene mitochondrial ribosomal protein L55

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. GJA12 mutations in children with recessive hypomyelinating leukoencephalopathy. Bugiani M, et al. Neurology, 2006 Jul 25. PMID 16707726
  2. Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model. Cui Y, et al. J Neuroinflammation, 2014 Mar 6. PMID 24597481, Free PMC Article
  3. Nigrostriatal proteomics of cypermethrin-induced dopaminergic neurodegeneration: microglial activation-dependent and -independent regulations. Singh AK, et al. Toxicol Sci, 2011 Aug. PMID 21561882
  4. Astrocytes regulate the expression of Sp1R3 on oligodendrocyte progenitor cells through Cx47 and promote their proliferation. Xu D, et al. Biochem Biophys Res Commun, 2017 Aug 26. PMID 28634078
  5. GJA12 mutations are a rare cause of Pelizaeus-Merzbacher-like disease. Henneke M, et al. Neurology, 2008 Mar 4. PMID 18094336

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of Chi3l1 expression.
    Title: Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of Chi3l1 expression.
  2. Astrocytes regulate the expression of S1pR3 in oligodendrocyte progenitor cells via Cx47, which could be a valuable approach for promoting oligodendrocyte progenitor cells proliferation.
    Title: Astrocytes regulate the expression of Sp1R3 on oligodendrocyte progenitor cells through Cx47 and promote their proliferation.
  3. Astrocytes can cause Ca(2+) signaling activation, ERK1/2 phosphorylation, and Id4 expression stimulation in oligodendrocyte progenitor cells inducing proliferation of these cells, mainly through Cx47.
    Title: Astrocytes induce proliferation of oligodendrocyte progenitor cells via connexin 47-mediated activation of the ERK/Id4 pathway.
  4. The study suggested that Cx47 play a key role in myelination.
    Title: Dynamic expression of Cx47 in mouse brain development and in the cuprizone model of myelin plasticity.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gap junction channel activity ISO
Inferred from Sequence Orthology
more info
  
enables gap junction channel activity involved in cell communication by electrical coupling ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell communication by electrical coupling ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-cell signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of oligodendrocyte progenitor proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to toxic substance ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of connexin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in gap junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in gap junction ISO
Inferred from Sequence Orthology
more info
  
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in paranode region of axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in proximal neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
gap junction gamma-2 protein
Names
connexin-47
gap junction alpha-12 protein
gap junction membrane channel protein alpha 12
gap junction protein, alpha 12

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100784.1 → NP_001094254.1  gap junction gamma-2 protein

    See identical proteins and their annotated locations for NP_001094254.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q80XF7
    Related
    ENSRNOP00000064383.1, ENSRNOT00000058362.5
    Conserved Domains (3) summary
    smart00037
    Location:45 → 78
    CNX; Connexin homologues
    smart01089
    Location:222 → 288
    Connexin_CCC; Gap junction channel protein cysteine-rich domain
    pfam00029
    Location:5 → 289
    Connexin; Connexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    44462203..44470924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246515.5 → XP_006246577.1  gap junction gamma-2 protein isoform X3

    See identical proteins and their annotated locations for XP_006246577.1

    UniProtKB/Swiss-Prot
    Q80XF7
    Conserved Domains (3) summary
    smart00037
    Location:45 → 78
    CNX; Connexin homologues
    smart01089
    Location:222 → 288
    Connexin_CCC; Gap junction channel protein cysteine-rich domain
    pfam00029
    Location:5 → 289
    Connexin; Connexin

  2. XM_039086565.2 → XP_038942493.1  gap junction gamma-2 protein isoform X1

    Related
    ENSRNOP00000102028.1, ENSRNOT00000167661.1
    Conserved Domains (1) summary
    pfam00029
    Location:96 → 381
    Connexin

  3. XM_063269613.1 → XP_063125683.1  gap junction gamma-2 protein isoform X2

  4. XM_039086566.2 → XP_038942494.1  gap junction gamma-2 protein isoform X4

    Conserved Domains (1) summary
    pfam00029
    Location:108 → 198
    Connexin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XF7.2 GenPept UniProtKB/Swiss-Prot:Q80XF7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous