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cobl cordon-bleu WH2 repeat protein [ Danio rerio (zebrafish) ]

Gene ID: 497312, updated on 18-Sep-2024

Summary

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Official Symbol
coblprovided by ZNC
Official Full Name
cordon-bleu WH2 repeat proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-091020-11
See related
Ensembl:ENSDARG00000091006 AllianceGenome:ZFIN:ZDB-GENE-091020-11
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7136115; si:ch211-207g17.1
Summary
Predicted to enable actin monomer binding activity. Acts upstream of or within cilium assembly and embryonic organ morphogenesis. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and ruffle. Is expressed in several structures, including Kupffer's vesicle; midbrain hindbrain boundary neural rod; nervous system; pronephros; and trunk. Orthologous to human COBL (cordon-bleu WH2 repeat protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See cobl in Genome Data Viewer
Location:
chromosome: 16
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (8530632..8663497, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (8617688..8749768, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene dopa decarboxylase Neighboring gene growth factor receptor-bound protein 10b Neighboring gene uncharacterized LOC137487877 Neighboring gene C-C chemokine receptor type 5-like Neighboring gene chemokine (C-C motif) receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The actin nucleator Cordon-bleu is required for development of motile cilia in zebrafish. Ravanelli AM, et al. Dev Biol, 2011 Feb 1. PMID 21129373, Free PMC Article
  2. Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl. Schüler S, et al. J Cell Sci, 2013 Jan 1. PMID 23203810
  3. From zebrafish heart jogging genes to mouse and human orthologs: using Gene Ontology to investigate mammalian heart development. Khodiyar VK, et al. F1000Res, 2013. PMID 24627794, Free PMC Article
  4. Phylogenetic and evolutionary relationships and developmental expression patterns of the zebrafish twist gene family. Yeo GH, et al. Dev Genes Evol, 2009 Jun. PMID 19565261
  5. Transcripts within rod photoreceptors of the Zebrafish retina. Sun C, et al. BMC Genomics, 2018 Feb 8. PMID 29422031, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within auditory receptor cell stereocilium organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart jogging IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein cordon-bleu
Names
cordon bleu
cordon-bleu homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289913.1 → NP_001276842.1  protein cordon-bleu

    Status: VALIDATED

    Source sequence(s)
    BX537113
    UniProtKB/Swiss-Prot
    E7F568, I1X3U9
    UniProtKB/TrEMBL
    A0A8M1P6G8, T1ECS5
    Related
    ENSDARP00000018030.8, ENSDART00000014944.10
    Conserved Domains (1) summary
    pfam09469
    Location:148 → 222
    Cobl; Cordon-bleu ubiquitin-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    8530632..8663497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021466684.2 → XP_021322359.1  protein cordon-bleu isoform X6

    UniProtKB/Swiss-Prot
    E7F568, I1X3U9
    UniProtKB/TrEMBL
    A0A2R8QQI2, A0A8M9PD33
    Related
    ENSDARP00000157032.1, ENSDART00000181533.1
    Conserved Domains (1) summary
    pfam09469
    Location:148 → 222
    Cobl; Cordon-bleu ubiquitin-like domain

  2. XM_002664800.7 → XP_002664846.2  protein cordon-bleu isoform X3

    UniProtKB/Swiss-Prot
    E7F568, I1X3U9
    UniProtKB/TrEMBL
    A0A8M1RKQ2
    Conserved Domains (1) summary
    pfam09469
    Location:148 → 222
    Cobl; Cordon-bleu ubiquitin-like domain

  3. XM_021466683.2 → XP_021322358.1  protein cordon-bleu isoform X5

    UniProtKB/Swiss-Prot
    E7F568, I1X3U9
    UniProtKB/TrEMBL
    A0A0R4IXG5, A0A8M9P7W5
    Related
    ENSDARP00000141202.1, ENSDART00000162988.3
    Conserved Domains (1) summary
    pfam09469
    Location:148 → 222
    Cobl; Cordon-bleu ubiquitin-like domain

  4. XM_021466681.2 → XP_021322356.1  protein cordon-bleu isoform X2

    UniProtKB/Swiss-Prot
    E7F568, I1X3U9
    UniProtKB/TrEMBL
    A0A8M9PJG4
    Conserved Domains (1) summary
    pfam09469
    Location:148 → 222
    Cobl; Cordon-bleu ubiquitin-like domain

  5. XM_005157875.5 → XP_005157932.1  protein cordon-bleu isoform X1

    UniProtKB/Swiss-Prot
    E7F568, I1X3U9
    UniProtKB/TrEMBL
    A0A2R8QQ65, A0A8M2B491
    Related
    ENSDARP00000156867.1, ENSDART00000182721.1
    Conserved Domains (1) summary
    pfam09469
    Location:148 → 222
    Cobl; Cordon-bleu ubiquitin-like domain

  6. XM_021466682.2 → XP_021322357.1  protein cordon-bleu isoform X4

    UniProtKB/Swiss-Prot
    E7F568, I1X3U9
    UniProtKB/TrEMBL
    A0A8M9NZ94
    Conserved Domains (1) summary
    pfam09469
    Location:133 → 207
    Cobl; Cordon-bleu ubiquitin-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E7F568.2 GenPept UniProtKB/Swiss-Prot:E7F568

Gene LinkOut

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