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pcbd1.L pterin-4 alpha-carbinolamine dehydratase 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 496367, updated on 4-Nov-2024

Summary

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Official Symbol
pcbd1.L
Official Full Name
pterin-4 alpha-carbinolamine dehydratase 1 L homeolog
Primary source
Xenbase:XB-GENE-6252156
Locus tag
XELAEV_18034919mg
See related
EnsemblRapid:ENSXLAG00005032680 AllianceGenome:Xenbase:XB-GENE-6252156
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
pcd; phs; dcoh; pcbd; Xdcoh
Summary
Predicted to enable 4-alpha-hydroxytetrahydrobiopterin dehydratase activity. Predicted to act upstream of or within tetrahydrobiopterin biosynthetic process. Predicted to be located in cytoplasm and nucleus. Is expressed in liver and biliary system and urinary system. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia D. Orthologous to human PCBD1 (pterin-4 alpha-carbinolamine dehydratase 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See pcbd1.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
4
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (45667128..45673019)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (43207854..43213745)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108696274 Neighboring gene U2 spliceosomal RNA Neighboring gene sphingosine-1-phosphate lyase 1 L homeolog Neighboring gene novel protein L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables 4-alpha-hydroxytetrahydrobiopterin dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within tetrahydrobiopterin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pterin-4-alpha-carbinolamine dehydratase-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095516.1 → NP_001088985.1  Pterin-4-alpha-carbinolamine dehydratase-like

    See identical proteins and their annotated locations for NP_001088985.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088970
    UniProtKB/Swiss-Prot
    Q5D030, Q91901
    UniProtKB/TrEMBL
    A0A974HBJ9, Q5HZL2
    Related
    ENSXLAP00005097990.1, ENSXLAT00005099797.1
    Conserved Domains (1) summary
    cd00914
    Location:24 → 99
    PCD_DCoH_subfamily_b; PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    45667128..45673019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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