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hrg hiiragi [ Drosophila melanogaster (fruit fly) ]

Gene ID: 49636, updated on 2-Nov-2024

Summary

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Official Symbol
hrgprovided by FlyBase
Official Full Name
hiiragiprovided by FlyBase
Primary source
FLYBASE:FBgn0015949
Locus tag
Dmel_CG9854
See related
AllianceGenome:FB:FBgn0015949
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9854; dHrg; Dmel\CG9854; Hiiragi; l(2)07619; l(2)k07619; Pap; PAP
Summary
Enables poly(A) RNA polymerase activity. Involved in cytosolic mRNA polyadenylation. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval midgut; epithelial cell; epithelium; ganglia; and gonad. Orthologous to several human genes including PAPOLA (poly(A) polymerase alpha) and PAPOLB (poly(A) polymerase beta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See hrg in Genome Data Viewer
Location:
56E1-56E1; 2-90 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19663919..19669832, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15551424..15557337, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44504 Neighboring gene mir-309 stem loop Neighboring gene uncharacterized protein Neighboring gene Kip1 ubiquitination-promoting complex subunit 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The hiiragi gene encodes a poly(A) polymerase, which controls the formation of the wing margin in Drosophila melanogaster. Murata T, et al. Dev Biol, 2001 May 1. PMID 11319863
  2. Modulating the bicoid gradient in space and time. Cai X, et al. Hereditas, 2021 Aug 17. PMID 34404481, Free PMC Article
  3. Maheshvara, a Conserved RNA Helicase, Regulates Notch Signaling in Drosophila melanogaster. Maurya B, et al. Adv Exp Med Biol, 2020. PMID 32072499
  4. The Drosophila PNG kinase complex regulates the translation of cyclin B. Vardy L, et al. Dev Cell, 2007 Jan. PMID 17199048
  5. Control of poly(A) polymerase level is essential to cytoplasmic polyadenylation and early development in Drosophila. Juge F, et al. EMBO J, 2002 Dec 2. PMID 12456666, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of novel regulators of dendrite arborization using cell type-specific RNA metabolic labeling.
    Title: Identification of novel regulators of dendrite arborization using cell type-specific RNA metabolic labeling.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(A) RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) RNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cytosolic mRNA polyadenylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hiiragi
Names
CG9854-PA
CG9854-PB
CG9854-PC
CG9854-PD
Poly(A) polymerase
hrg-PA
hrg-PB
hrg-PC
hrg-PD
poly (A) polymerase
NP_001036562.1
NP_001261097.1
NP_536790.1
NP_725919.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19663919..19669832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080529.4 → NP_536790.1  hiiragi, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_536790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZ09, Q9N6D7
    Related
    FBpp0085678
    Conserved Domains (3) summary
    PTZ00418
    Location:28 → 600
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:374 → 534
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:29 → 371
    PAP_central; Poly(A) polymerase central domain

  2. NM_001274168.2 → NP_001261097.1  hiiragi, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261097.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG96
    Conserved Domains (3) summary
    PTZ00418
    Location:28 → 600
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:374 → 534
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:29 → 371
    PAP_central; Poly(A) polymerase central domain

  3. NM_166372.3 → NP_725919.1  hiiragi, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725919.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZ09, Q9N6D7
    Related
    FBpp0085679
    Conserved Domains (3) summary
    PTZ00418
    Location:28 → 600
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:374 → 534
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:29 → 371
    PAP_central; Poly(A) polymerase central domain

  4. NM_001043097.3 → NP_001036562.1  hiiragi, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036562.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MZ09, Q9N6D7
    Conserved Domains (3) summary
    PTZ00418
    Location:28 → 600
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:374 → 534
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:29 → 371
    PAP_central; Poly(A) polymerase central domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KG96 A0A0B4KG96
Q8MZ09 Q8MZ09
Q9N6D7 Q9N6D7
Q9NDU1 Q9NDU1
Q9NDU2 Q9NDU2

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