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HHV8GK18_gp83 K14 [ Human gammaherpesvirus 8 ]

Gene ID: 4961465, updated on 18-Aug-2023

Summary

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Gene symbol
HHV8GK18_gp83
Gene description
K14
Locus tag
HHV8GK18_gp83
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (127966..130671)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF71 Neighboring gene ORF72 Neighboring gene ORF73 Neighboring gene ORF74 Neighboring gene ORF75 Neighboring gene K15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kaposi's sarcoma-associated herpesvirus G-protein coupled receptor activates the canonical Wnt/β-catenin signaling pathway. Angelova M, et al. Virol J, 2014 Dec 17. PMID 25514828, Free PMC Article
  2. Kaposi's sarcoma-associated herpesvirus G-protein-coupled receptor prevents AU-rich-element-mediated mRNA decay. Corcoran JA, et al. J Virol, 2012 Aug. PMID 22696654, Free PMC Article
  3. Herpesvirus orthologues of CD200 bind host CD200R but not related activating receptors. Kwong LS, et al. J Gen Virol, 2016 Jan. PMID 26538068, Free PMC Article
  4. The guanine exchange factor SWAP70 mediates vGPCR-induced endothelial plasticity. Dwyer J, et al. Cell Commun Signal, 2015 Feb 15. PMID 25889342, Free PMC Article
  5. The unsulfated extracellular N-terminus of vGPCR reduces the tumorigenicity of hGRO-α in nude mice. Wu H, et al. Sci China Life Sci, 2013 Jan. PMID 23269549

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors showed that the viral orthologues e127 from rat cytomegalovirus and K14 from human herpesvirus 8 do not bind the activating CD200R-like proteins from their respective species, although they do bind the inhibitory receptors.
    Title: Herpesvirus orthologues of CD200 bind host CD200R but not related activating receptors.
  2. In this study, the authors identify a novel pathway, the Wnt/beta-catenin pathway, which is dysregulated by vGPCR expression in endothelial cells.
    Title: Kaposi's sarcoma-associated herpesvirus G-protein coupled receptor activates the canonical Wnt/β-catenin signaling pathway.
  3. SWAP70 appears to act as a molecular intermediate between vGPCR and endothelial activation.
    Title: The guanine exchange factor SWAP70 mediates vGPCR-induced endothelial plasticity.
  4. Data indicate that in NIH3T3 cells expressing unsulfated vGPCR mutant (yydd-vGN) but not vGPCR (wt-vGN) could significantly inhibit the tumor growth triggered by hGRO-alpha.
    Title: The unsulfated extracellular N-terminus of vGPCR reduces the tumorigenicity of hGRO-α in nude mice.
  5. By suppressing cis-acting AU-rich elements-mRNA turnover, vGPCR may facilitate escape of certain target mRNAs from host shutoff and allow secretion of angiogenic factors from lytically infected cells.
    Title: Kaposi's sarcoma-associated herpesvirus G-protein-coupled receptor prevents AU-rich-element-mediated mRNA decay.
  6. the TSC/mTOR/HIF axis is activated by the KSHV vGPCR in Kaposi's sarcoma, which amplifies the angiogenic signal
    Title: Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.
  7. Phosphorylation and polyubiquitination of TAK1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus vGPCR.
    Title: Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.
  8. The authors show that vGPCR contains a bona fide immunoreceptor tyrosine-based inhibitory motif (ITIM) that binds and constitutively activates Shp2.
    Title: The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor contains an immunoreceptor tyrosine-based inhibitory motif that activates Shp2.
  9. vGPCR up-regulation of ANGPTL4 plays a prominent role in promoting the angiogenesis and vessel permeability observed in Kaposi's sarcoma
    Title: Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

regulatory

  • Loc: 127966-127971 regulatory_class = TATA_box
  • Loc: 130666-130671 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
K14
YP_001129432.1
  • contains two Ig domains

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    127966..130671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129432.1 K14 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129432.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0C788, P0C789, P88963, Q98149
    UniProtKB/TrEMBL
    A0A0N9RQY8, O40948
    Conserved Domains (2) summary
    cd00096
    Location:33 → 41
    Ig; Ig strand B [structural motif]
    cl11960
    Location:33 → 127
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version

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