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HHV8GK18_gp84 ORF74 [ Human gammaherpesvirus 8 ]

Gene ID: 4961460, updated on 18-Aug-2023

Summary

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Gene symbol
HHV8GK18_gp84
Gene description
ORF74
Locus tag
HHV8GK18_gp84
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
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Genomic context

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Sequence:
NC_009333.1 (129520..130671)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene ORF71 Neighboring gene ORF72 Neighboring gene ORF73 Neighboring gene K14 Neighboring gene ORF75 Neighboring gene K15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The viral G protein-coupled receptor ORF74 unmasks phospholipase C signaling of the receptor tyrosine kinase IGF-1R. de Munnik SM, et al. Cell Signal, 2016 Jun. PMID 26931381
  2. The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines. de Munnik SM, et al. PLoS One, 2015. PMID 25894435, Free PMC Article
  3. Glycosylation of KSHV encoded vGPCR functions in its signaling and tumorigenicity. Wu H, et al. Viruses, 2015 Mar 31. PMID 25835533, Free PMC Article
  4. YGLF motif in the Kaposi sarcoma herpes virus G-protein-coupled receptor adjusts NF-κB activation and paracrine actions. Azzi S, et al. Oncogene, 2014 Dec 4. PMID 24292677
  5. Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis. Dong X, et al. Proc Natl Acad Sci U S A, 2016 Mar 15. PMID 26929373, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unmasking IGF-1R signaling to PLC in response to IGF-1 is a previously unrecognized action of ORF74.
    Title: The viral G protein-coupled receptor ORF74 unmasks phospholipase C signaling of the receptor tyrosine kinase IGF-1R.
  2. Beclin 2, interacts with KSHV GPCR, encoded by ORF74, facilitates its endolysosomal degradation, and inhibits vGPCR-driven oncogenic signaling.
    Title: Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.
  3. ORF74 recruits beta-arrestins and subsequently internalizes in response to human chemokines
    Title: The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines.
  4. These findings support the conclusion that glycosylation is critical for viral G protein-coupled receptor (vGPCR) tumorigenesis and imply that chemokine regulation at the plasma membrane is crucial for vGPCR mediated signaling.
    Title: Glycosylation of KSHV encoded vGPCR functions in its signaling and tumorigenicity.
  5. the YGLF motif in the Kaposi sarcoma herpes virus G-protein-coupled receptor adjusts NF-kappaB activation and paracrine actions
    Title: YGLF motif in the Kaposi sarcoma herpes virus G-protein-coupled receptor adjusts NF-κB activation and paracrine actions.
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General gene information

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Homology

regulatory

  • Loc: 130666-130671 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
ORF74
Names
vGPCR
YP_001129433.1
  • similar to IL-8 receptor; transforming protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    129520..130671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129433.1 ORF74 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129433.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    O12573, P88966, Q77Q35, Q98146
    UniProtKB/TrEMBL
    A0A7D5UH77, O90387, Q76SF8, Q9QEV2
    Conserved Domains (2) summary
    cd14964
    Location:53 → 75
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:53 → 325
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein
Heading Accession and Version

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