tmem53.S transmembrane protein 53 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tmem53.S
Official Full Name: transmembrane protein 53 S homeolog
Primary source: Xenbase:XB-GENE-1018177
Locus tag: XELAEV_18025210mg
See related: EnsemblRapid:ENSXLAG00005023478 AllianceGenome:Xenbase:XB-GENE-1018177
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: net4; tmem53; tmem53-a; tmem53-b
Summary: Predicted to act upstream of or within several processes, including negative regulation of BMP signaling pathway; negative regulation of ossification; and negative regulation of osteoblast differentiation. Predicted to be located in nuclear outer membrane. Human ortholog(s) of this gene implicated in craniotubular dysplasia Ikegawa type. Orthologous to human TMEM53 (transmembrane protein 53). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4S

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (71349778..71353982)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4S	NC_030731.1 (65124139..65128351)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of ossification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of nucleocytoplasmic transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane protein 53-A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.