nme4.S NME/NM23 nucleoside diphosphate kinase 4 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: nme4.S
Official Full Name: NME/NM23 nucleoside diphosphate kinase 4 S homeolog
Primary source: Xenbase:XB-GENE-6253015
Locus tag: XELAEV_18047701mg
See related: EnsemblRapid:ENSXLAG00005008398 AllianceGenome:Xenbase:XB-GENE-6253015
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: nme4; nme4b; ndpk-d; nm23h4; nme4-a; nme4-b; NM23-X4; nm23-h4
Summary: Predicted to enable ATP binding activity and nucleoside diphosphate kinase activity. Predicted to act upstream of or within phosphorylation and ribonucleoside triphosphate biosynthetic process. Orthologous to human NME4 (NME/NM23 nucleoside diphosphate kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (100747102..100764028, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (94122410..94139354, complement)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that NM23-X4, a NM23 family member, as a binding partner of p27Xic1, regulates retinal gliogenesis through interaction with p27Xic1 in Xenopus.
Title: Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleoside diphosphate kinase 4

Names: non-metastatic cells 4, protein expressed in b

NP_001088687.1

EC 2.7.4.6

XP_018093061.1

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001095218.1 → NP_001088687.1 nucleoside diphosphate kinase 4

See identical proteins and their annotated locations for NP_001088687.1

Status: PROVISIONAL

Source sequence(s)

BC087320

UniProtKB/TrEMBL

A0A974BVP4, Q5PQ84

Conserved Domains (2) summary

cd04413
Location:32 → 161

NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...

pfam00334
Location:32 → 166

NDK; Nucleoside diphosphate kinase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

100747102..100764028 complement

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GenBank, FASTA, Sequence Viewer (Graphics)