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psenen.L presenilin enhancer, gamma-secretase subunit L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495936, updated on 4-Nov-2024

Summary

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Official Symbol
psenen.L
Official Full Name
presenilin enhancer, gamma-secretase subunit L homeolog
Primary source
Xenbase:XB-GENE-17346699
Locus tag
XELAEV_18036462mg
See related
EnsemblRapid:ENSXLAG00005015397 AllianceGenome:Xenbase:XB-GENE-17346699
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Predicted to act upstream of or within Notch receptor processing and Notch signaling pathway. Predicted to be located in Golgi cisterna membrane. Predicted to be part of gamma-secretase complex. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See psenen.L in Genome Data Viewer
Location:
chromosome: 7L
Exon count:
5
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 7L NC_054383.1 (135175728..135183580, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 7L NC_030736.1 (122258984..122266787)

Chromosome 7L - NC_054383.1Genomic Context describing neighboring genes Neighboring gene protein lin-37 homolog Neighboring gene heat shock protein family B (small) member 6 L homeolog Neighboring gene lysine methyltransferase 2B L homeolog Neighboring gene zinc finger protein 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within Notch receptor processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
part_of gamma-secretase complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Gamma-secretase subunit PEN-2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095205.1 → NP_001088674.1  Gamma-secretase subunit PEN-2-like

    See identical proteins and their annotated locations for NP_001088674.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087298
    UniProtKB/TrEMBL
    A0A974CIV4, Q5PQA0
    Related
    ENSXLAP00005045120.1, ENSXLAT00005046219.1
    Conserved Domains (1) summary
    pfam10251
    Location:7 → 99
    PEN-2; Presenilin enhancer-2 subunit of gamma secretase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054383.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    135175728..135183580 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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