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tnpo2.L transportin 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495499, updated on 4-Nov-2024

Summary

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Official Symbol
tnpo2.L
Official Full Name
transportin 2 L homeolog
Primary source
Xenbase:XB-GENE-968455
Locus tag
XELAEV_18019089mg
See related
EnsemblRapid:ENSXLAG00005001989 AllianceGenome:Xenbase:XB-GENE-968455
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
tnpo2; tnpo2.S
Summary
Predicted to enable nuclear import signal receptor activity; nuclear localization sequence binding activity; and small GTPase binding activity. Predicted to act upstream of or within protein import into nucleus. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in intellectual developmental disorder with hypotonia, impaired speech, and dysmorphic facies. Orthologous to human TNPO2 (transportin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tnpo2.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
25
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (149991404..150018687)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (133088865..133116173)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene telomerase RNA component interacting RNase L homeolog Neighboring gene RING finger protein 11 Neighboring gene small nucleolar RNA SNORD41 Neighboring gene deoxyhypusine synthase L homeolog Neighboring gene WD repeat domain 83 L homeolog Neighboring gene WD repeat domain 83 opposite strand L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables nuclear import signal receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nuclear localization sequence binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transportin 2 L homeolog
Names
transportin 2 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095139.1 → NP_001088608.1  transportin 2 L homeolog

    See identical proteins and their annotated locations for NP_001088608.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084978
    UniProtKB/TrEMBL
    A0A974DEB5, Q5U4R8
    Related
    ENSXLAP00005006000.1, ENSXLAT00005006106.1
    Conserved Domains (5) summary
    COG5215
    Location:15 → 759
    KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]
    cd00020
    Location:125 → 240
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    pfam03810
    Location:32 → 99
    IBN_N; Importin-beta N-terminal domain
    pfam13513
    Location:411 → 465
    HEAT_EZ; HEAT-like repeat
    sd00044
    Location:127 → 155
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    149991404..150018687
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018251145.2 → XP_018106634.1  transportin 2 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UG17

  2. XM_018251144.2 → XP_018106633.1  transportin 2 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J0UG17
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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