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tdo2.L tryptophan 2,3-dioxygenase L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495495, updated on 4-Nov-2024

Summary

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Official Symbol
tdo2.L
Official Full Name
tryptophan 2,3-dioxygenase L homeolog
Primary source
Xenbase:XB-GENE-976717
Locus tag
XELAEV_18005453mg
See related
EnsemblRapid:ENSXLAG00005032487 AllianceGenome:Xenbase:XB-GENE-976717
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
tdo2
Summary
Predicted to enable tryptophan 2,3-dioxygenase activity. Predicted to act upstream of or within protein homotetramerization and tryptophan catabolic process to kynurenine. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tdo2.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
12
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (57117141..57134822, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (46803904..46821720, complement)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene platelet derived growth factor C L homeolog Neighboring gene cathepsin O L homeolog Neighboring gene guanylate cyclase 1 soluble subunit beta 1 L homeolog Neighboring gene guanylate cyclase 1 soluble subunit alpha 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan 2,3-dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan 2,3-dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein homotetramerization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within tryptophan catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tryptophan catabolic process to acetyl-CoA IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tryptophan catabolic process to kynurenine IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tryptophan catabolic process to kynurenine ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
tryptophan 2,3-dioxygenase
NP_001088604.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095135.1 → NP_001088604.1  tryptophan 2,3-dioxygenase

    See identical proteins and their annotated locations for NP_001088604.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084948
    UniProtKB/Swiss-Prot
    Q5U4U6
    UniProtKB/TrEMBL
    A0A974DY50
    Related
    ENSXLAP00005097320.1, ENSXLAT00005099106.1
    Conserved Domains (1) summary
    pfam03301
    Location:26 → 372
    Trp_dioxygenase; Tryptophan 2,3-dioxygenase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    57117141..57134822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U4U6.1 GenPept UniProtKB/Swiss-Prot:Q5U4U6

Gene LinkOut

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