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apba2.S amyloid beta (A4) precursor protein-binding, family A, member 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495441, updated on 4-Nov-2024

Summary

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Official Symbol
apba2.S
Official Full Name
amyloid beta (A4) precursor protein-binding, family A, member 2 S homeolog
Primary source
Xenbase:XB-GENE-17341865
Locus tag
XELAEV_18020694mg
See related
EnsemblRapid:ENSXLAG00005009008 AllianceGenome:Xenbase:XB-GENE-17341865
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Predicted to enable amyloid-beta binding activity. Predicted to act upstream of or within chemical synaptic transmission. Predicted to be located in cytoplasm; dendritic spine; and plasma membrane. Orthologous to human APBA2 (amyloid beta precursor protein binding family A member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See apba2.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
17
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (56550588..56696689, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (55231089..55384632, complement)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene tight junction protein ZO-1 Neighboring gene endosomal transmembrane epsin interactor 2 S homeolog Neighboring gene U3 small nucleolar ribonucleoprotein protein MPP10-like Neighboring gene methylmalonyl-CoA epimerase S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC495441

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001095095.1 → NP_001088564.1  uncharacterized protein LOC495441

    See identical proteins and their annotated locations for NP_001088564.1

    Status: PREDICTED

    Source sequence(s)
    BC084963
    UniProtKB/TrEMBL
    A0A974DEK9, A0A974HR92, Q5U4T1
    Related
    ENSXLAP00005026190.1, ENSXLAT00005026923.1
    Conserved Domains (3) summary
    cd00992
    Location:644 → 717
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:362 → 522
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:555 → 636
    PDZ; PDZ domain (Also known as DHR or GLGF)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    56550588..56696689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018254382.2 → XP_018109871.1  uncharacterized protein LOC495441 isoform X1

    UniProtKB/TrEMBL
    A0A8J1MRH3, A0A974DEK9
    Conserved Domains (4) summary
    cd00992
    Location:656 → 729
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:362 → 534
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    TIGR00927
    Location:28 → 231
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam00595
    Location:567 → 648
    PDZ; PDZ domain (Also known as DHR or GLGF)

  2. XM_018254381.2 → XP_018109870.1  uncharacterized protein LOC495441 isoform X1

    UniProtKB/TrEMBL
    A0A8J1MRH3, A0A974DEK9
    Conserved Domains (4) summary
    cd00992
    Location:656 → 729
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:362 → 534
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    TIGR00927
    Location:28 → 231
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam00595
    Location:567 → 648
    PDZ; PDZ domain (Also known as DHR or GLGF)

  3. XM_041587701.1 → XP_041443635.1  uncharacterized protein LOC495441 isoform X1

    UniProtKB/TrEMBL
    A0A8J1MRH3, A0A974DEK9
    Conserved Domains (4) summary
    cd00992
    Location:656 → 729
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:362 → 534
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    TIGR00927
    Location:28 → 231
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam00595
    Location:567 → 648
    PDZ; PDZ domain (Also known as DHR or GLGF)

  4. XM_018254383.2 → XP_018109872.1  uncharacterized protein LOC495441 isoform X1

    UniProtKB/TrEMBL
    A0A8J1MRH3, A0A974DEK9
    Related
    ENSXLAP00005026179.1, ENSXLAT00005026910.1
    Conserved Domains (4) summary
    cd00992
    Location:656 → 729
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:362 → 534
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    TIGR00927
    Location:28 → 231
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam00595
    Location:567 → 648
    PDZ; PDZ domain (Also known as DHR or GLGF)

  5. XM_041587700.1 → XP_041443634.1  uncharacterized protein LOC495441 isoform X1

    UniProtKB/TrEMBL
    A0A8J1MRH3, A0A974DEK9
    Conserved Domains (4) summary
    cd00992
    Location:656 → 729
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:362 → 534
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    TIGR00927
    Location:28 → 231
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam00595
    Location:567 → 648
    PDZ; PDZ domain (Also known as DHR or GLGF)

  6. XM_018254384.2 → XP_018109873.1  uncharacterized protein LOC495441 isoform X1

    UniProtKB/TrEMBL
    A0A8J1MRH3, A0A974DEK9
    Conserved Domains (4) summary
    cd00992
    Location:656 → 729
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:362 → 534
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    TIGR00927
    Location:28 → 231
    2A1904; K+-dependent Na+/Ca+ exchanger
    pfam00595
    Location:567 → 648
    PDZ; PDZ domain (Also known as DHR or GLGF)
Nucleotide Protein Strain
Heading Accession and Version

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