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styx.S serine/threonine/tyrosine interacting protein S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495329, updated on 4-Nov-2024

Summary

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Official Symbol
styx.S
Official Full Name
serine/threonine/tyrosine interacting protein S homeolog
Primary source
Xenbase:XB-GENE-6253970
Locus tag
XELAEV_18041230mg
See related
EnsemblRapid:ENSXLAG00005003624 AllianceGenome:Xenbase:XB-GENE-6253970
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
styx; styx-a; styx-b
Summary
Predicted to enable F-box domain binding activity. Predicted to act upstream of or within negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process; protein dephosphorylation; and regulation of ERK1 and ERK2 cascade. Predicted to be located in cytoplasm and nucleoplasm. Orthologous to human STYX (serine/threonine/tyrosine interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See styx.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
10
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (14240780..14259514, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (14174383..14193107, complement)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene DDHD domain containing 1 S homeolog Neighboring gene FERM domain containing kindlin 2 S homeolog Neighboring gene proteasome 26S subunit, ATPase 6 S homeolog Neighboring gene ADP ribosylation factor 6 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables F-box domain binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine/tyrosine-interacting protein B
Names
inactive tyrosine-protein phosphatase STYX-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094995.1 → NP_001088464.1  serine/threonine/tyrosine-interacting protein B

    See identical proteins and their annotated locations for NP_001088464.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084791
    UniProtKB/Swiss-Prot
    Q5U593
    UniProtKB/TrEMBL
    A0A974C1T2
    Related
    ENSXLAP00005010782.1, ENSXLAT00005010956.1
    Conserved Domains (1) summary
    cd00127
    Location:28 → 171
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    14240780..14259514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041574289.1 → XP_041430223.1  serine/threonine/tyrosine-interacting protein B isoform X3

    UniProtKB/TrEMBL
    A0A8J1LKX9
    Conserved Domains (1) summary
    cd14522
    Location:25 → 150
    DSP_STYX; dual specificity phosphatase-like domain of serine/threonine/tyrosine-interacting protein

  2. XM_041574287.1 → XP_041430221.1  serine/threonine/tyrosine-interacting protein B isoform X1

    UniProtKB/TrEMBL
    A0A8J1LLW7, A0A974C1T2
    Conserved Domains (1) summary
    cd14522
    Location:25 → 157
    DSP_STYX; dual specificity phosphatase-like domain of serine/threonine/tyrosine-interacting protein

  3. XM_018232075.2 → XP_018087564.1  serine/threonine/tyrosine-interacting protein B isoform X2

    UniProtKB/TrEMBL
    A0A8J0TPM4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U593.1 GenPept UniProtKB/Swiss-Prot:Q5U593

Gene LinkOut

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