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nrarp.S NOTCH regulated ankyrin repeat protein S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495317, updated on 4-Nov-2024

Summary

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Official Symbol
nrarp.S
Official Full Name
NOTCH regulated ankyrin repeat protein S homeolog
Primary source
Xenbase:XB-GENE-996962
Locus tag
XELAEV_18041456mg
See related
EnsemblRapid:ENSXLAG00005011817 AllianceGenome:Xenbase:XB-GENE-996962
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
XNAP; nrarp; nrarp.L
Summary
Predicted to enable enzyme inhibitor activity and phosphatase regulator activity. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in cytoplasm. Is expressed in musculoskeletal system; nervous system; and primary germ layer. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nrarp.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
1
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (27297659..27300220, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (27172192..27174795, complement)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene protein AMBP-like Neighboring gene olfactory binding protein S homeolog Neighboring gene uncharacterized LOC108699876 Neighboring gene uncharacterized LOC108701113

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nrarp is a novel intracellular component of the Notch signaling pathway. Lamar E, et al. Genes Dev, 2001 Aug 1. PMID 11485984, Free PMC Article
  2. Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability. Ishitani T, et al. Nat Cell Biol, 2005 Nov. PMID 16228014
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables enzyme inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Notch signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
notch-regulated ankyrin repeat-containing protein
Names
NOTCH-regulated ankyrin repeat protein L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094984.1 → NP_001088453.1  notch-regulated ankyrin repeat-containing protein

    See identical proteins and their annotated locations for NP_001088453.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084778
    UniProtKB/Swiss-Prot
    Q5U5A6
    UniProtKB/TrEMBL
    A0A974C2G0
    Related
    ENSXLAP00005034522.1, ENSXLAT00005035405.1
    Conserved Domains (3) summary
    cd00204
    Location:21 → 104
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13637
    Location:53 → 104
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:50 → 81
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    27297659..27300220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U5A6.1 GenPept UniProtKB/Swiss-Prot:Q5U5A6

Gene LinkOut

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