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p2ry12.L purinergic receptor P2Y, G-protein coupled, 12 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495243, updated on 4-Nov-2024

Summary

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Official Symbol
p2ry12.L
Official Full Name
purinergic receptor P2Y, G-protein coupled, 12 L homeolog
Primary source
Xenbase:XB-GENE-947456
Locus tag
XELAEV_18027698mg
See related
EnsemblRapid:ENSXLAG00005016878 AllianceGenome:Xenbase:XB-GENE-947456
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
p2ry12
Summary
Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and blood coagulation. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See p2ry12.L in Genome Data Viewer
Location:
chromosome: 5L
Exon count:
4
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (126101554..126149373)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (115351709..115399525)

Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene arylacetamide deacetylase L homeolog Neighboring gene immunoglobulin superfamily member 10 L homeolog Neighboring gene purinergic receptor P2Y, G-protein coupled, 13 L homeolog Neighboring gene G protein-coupled receptor 87 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables G protein-coupled purinergic nucleotide receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
purinergic receptor P2Y, G-protein coupled, 12 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094921.1 → NP_001088390.2  purinergic receptor P2Y, G-protein coupled, 12 L homeolog

    Status: PROVISIONAL

    Source sequence(s)
    BC084665
    UniProtKB/TrEMBL
    A0A1L8GAY7, A0A974CY35, Q5XG06
    Related
    ENSXLAP00005049713.1, ENSXLAT00005050854.1
    Conserved Domains (1) summary
    cd15150
    Location:35 → 319
    7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    126101554..126149373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041562266.1 → XP_041418200.1  purinergic receptor P2Y, G-protein coupled, 12 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8GAY7, A0A974CY35, Q5XG06
    Conserved Domains (1) summary
    cd15150
    Location:35 → 319
    7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_018262032.2 → XP_018117521.1  purinergic receptor P2Y, G-protein coupled, 12 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8GAY7, A0A974CY35, Q5XG06
    Conserved Domains (1) summary
    cd15150
    Location:35 → 319
    7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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