smdt1.S single-pass membrane protein with aspartate-rich tail 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: smdt1.S
Official Full Name: single-pass membrane protein with aspartate-rich tail 1 S homeolog
Primary source: Xenbase:XB-GENE-1002280
Locus tag: XELAEV_18025558mg
See related: AllianceGenome:Xenbase:XB-GENE-1002280
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: emre; smdt1; c22orf32
Summary: Predicted to enable channel activator activity and protein-macromolecule adaptor activity. Predicted to act upstream of or within calcium import into the mitochondrion and mitochondrial calcium ion homeostasis. Predicted to be located in mitochondrion. Predicted to be part of uniplex complex. Predicted to be active in mitochondrial inner membrane. Orthologous to human SMDT1 (single-pass membrane protein with aspartate rich tail 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 4S

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (94536918..94541083, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4S	NC_030731.1 (88209096..88213261, complement)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables channel activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium import into the mitochondrion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium import into the mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitochondrial calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitochondrial calcium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of uniplex complex	IEA Inferred from Electronic Annotation more info
part_of uniplex complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: essential MCU regulator, mitochondrial

Names: UPF0466 protein C22orf32 homolog, mitochondrial; single-pass membrane protein with aspartate-rich tail 1, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001094892.1 → NP_001088361.1 essential MCU regulator, mitochondrial precursor

See identical proteins and their annotated locations for NP_001088361.1

Status: PROVISIONAL

Source sequence(s)

BC084597

UniProtKB/Swiss-Prot

Q5XG64

UniProtKB/TrEMBL

A0A974D286

Conserved Domains (1) summary

pfam10161
Location:32 → 91

DDDD; Putative mitochondrial precursor protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

94536918..94541083 complement

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GenBank, FASTA, Sequence Viewer (Graphics)