ric8a.S RIC8 guanine nucleotide exchange factor A S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ric8a.S
Official Full Name: RIC8 guanine nucleotide exchange factor A S homeolog
Primary source: Xenbase:XB-GENE-5745170
Locus tag: XELAEV_18037787mg
See related: EnsemblRapid:ENSXLAG00005011782 AllianceGenome:Xenbase:XB-GENE-5745170
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: Syn; ric-8; ric8a; ric-8A; ric8a-a; ric8a-b; ric8a.L; ricc8aa; xtric-8; synembryn
Summary: Predicted to enable G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and protein folding chaperone. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm and plasma membrane. Is expressed in ectoderm; musculoskeletal system; nervous system; pharyngeal arch; and visual system. Orthologous to human RIC8A (RIC8 guanine nucleotide exchange factor A). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 7S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	7S	NC_054384.1 (97065517..97106061)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	7S	NC_030737.1 (77926794..77967468)

Chromosome 7S - NC_054384.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that xRic-8 is participating in the immature oocyte by keeping Gsalpha-Gbetagamma-AC signaling complex in an activated state and therefore maintaining G2 arrest.
Title: xRic-8 is a GEF for Gsalpha and participates in maintaining meiotic arrest in Xenopus laevis oocytes.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IEA Inferred from Electronic Annotation more info
enables G-protein alpha-subunit binding	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein folding chaperone	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: synembryn-A

Names: Protein Ric-8A; RIC8 guanine nucleotide exchange factor A L homeolog; resistance to inhibitors of cholinesterase 8 homolog A a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.