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nebl.L nebulette L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495167, updated on 4-Nov-2024

Summary

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Official Symbol
nebl.L
Official Full Name
nebulette L homeolog
Primary source
Xenbase:XB-GENE-17339415
Locus tag
XELAEV_18030801mg
See related
EnsemblRapid:ENSXLAG00005028623 AllianceGenome:Xenbase:XB-GENE-17339415
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Summary
Predicted to enable actin filament binding activity and metal ion binding activity. Predicted to be located in cytoplasm and focal adhesion. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human NEBL (nebulette). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nebl.L in Genome Data Viewer
Location:
chromosome: 6L
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6L NC_054381.1 (26759137..26905186)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6L NC_030734.1 (24272980..24416771)

Chromosome 6L - NC_054381.1Genomic Context describing neighboring genes Neighboring gene MLLT10, histone lysine methyltransferase DOT1L cofactor L homeolog Neighboring gene SKI/DACH domain containing 1 L homeolog Neighboring gene nebulette-like Neighboring gene plexin domain containing 2 L homeolog Neighboring gene MAM and LDL receptor class A domain containing 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nebulette

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094860.1 → NP_001088329.1  nebulette

    See identical proteins and their annotated locations for NP_001088329.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084378
    UniProtKB/TrEMBL
    Q5XGQ5
    Related
    ENSXLAP00005085196.1, ENSXLAT00005086858.1
    Conserved Domains (3) summary
    smart00227
    Location:62 → 92
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:5 → 57
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11935
    Location:218 → 275
    SH3_Nebulette_C; C-terminal Src Homology 3 domain of Nebulette and LIM-nebulette (or Lasp2)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    26759137..26905186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041565542.1 → XP_041421476.1  nebulette isoform X2

    UniProtKB/TrEMBL
    A0A8J1KVZ6
    Conserved Domains (2) summary
    smart00227
    Location:62 → 92
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:5 → 57
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)

  2. XM_041565541.1 → XP_041421475.1  nebulette isoform X1

    UniProtKB/TrEMBL
    A0A8J1KVZ0
    Related
    ENSXLAP00005085154.1, ENSXLAT00005086816.1
    Conserved Domains (3) summary
    smart00227
    Location:62 → 92
    NEBU; The Nebulin repeat is present also in Las1
    cd09447
    Location:5 → 57
    LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
    cd11935
    Location:266 → 323
    SH3_Nebulette_C; C-terminal Src Homology 3 domain of Nebulette and LIM-nebulette (or Lasp2)
Nucleotide Protein Strain
Heading Accession and Version

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