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ltc4s.2.L leukotriene C4 synthase, gene 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495166, updated on 4-Nov-2024

Summary

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Official Symbol
ltc4s.2.L
Official Full Name
leukotriene C4 synthase, gene 2 L homeolog
Primary source
Xenbase:XB-GENE-981582
Locus tag
XELAEV_18016940mg
See related
EnsemblRapid:ENSXLAG00005001615 AllianceGenome:Xenbase:XB-GENE-981582
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
mgst2; ltc4s.2
Summary
Predicted to enable several functions, including glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Predicted to act upstream of or within leukotriene biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and nuclear outer membrane. Orthologous to human LTC4S (leukotriene C4 synthase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ltc4s.2.L in Genome Data Viewer
Location:
chromosome: 3L
Exon count:
8
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3L NC_054375.1 (27954201..27971573, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3L NC_030728.1 (15038539..15058730, complement)

Chromosome 3L - NC_054375.1Genomic Context describing neighboring genes Neighboring gene catenin alpha 1 L homeolog Neighboring gene DAP3 binding cell death enhancer 1 L homeolog Neighboring gene protocadherin 12 L homeolog Neighboring gene calnexin L homeolog Neighboring gene uncharacterized LOC121401428

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene-C4 synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within leukotriene biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within leukotriene metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
leukotriene C4 synthase, gene 2 L homeolog
Names
LTC4 synthase
microsomal glutathione S-transferase 2
NP_001088328.1
XP_041441129.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094859.2 → NP_001088328.1  leukotriene C4 synthase, gene 2 L homeolog

    See identical proteins and their annotated locations for NP_001088328.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084377
    UniProtKB/TrEMBL
    A0A974DCB1, Q5XGQ6
    Conserved Domains (1) summary
    pfam01124
    Location:8 → 122
    MAPEG; MAPEG family

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    27954201..27971573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041585195.1 → XP_041441129.1  leukotriene C4 synthase, gene 2 L homeolog isoform X1

    UniProtKB/TrEMBL
    A0A8J1MHD1
    Related
    ENSXLAP00005004835.1, ENSXLAT00005004932.1
    Conserved Domains (1) summary
    cl09190
    Location:1 → 70
    MAPEG; MAPEG family
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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