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dusp6.S dual specificity phosphatase 6 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495060, updated on 4-Nov-2024

Summary

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Official Symbol
dusp6.S
Official Full Name
dual specificity phosphatase 6 S homeolog
Primary source
Xenbase:XB-GENE-17333168
Locus tag
XELAEV_18021247mg
See related
EnsemblRapid:ENSXLAG00005021163 AllianceGenome:Xenbase:XB-GENE-17333168
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
X17C; mkp3; pyst1
Summary
Predicted to enable phosphoprotein phosphatase activity. Predicted to act upstream of or within several processes, including negative regulation of ERK1 and ERK2 cascade; protein dephosphorylation; and regulation of heart growth. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to human DUSP6 (dual specificity phosphatase 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dusp6.S in Genome Data Viewer
Location:
chromosome: 3S
Exon count:
3
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 3S NC_054376.1 (92643743..92649716)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 3S NC_030729.1 (90816807..90822780)

Chromosome 3S - NC_054376.1Genomic Context describing neighboring genes Neighboring gene epiphycan S homeolog Neighboring gene ATPase, Ca++ transporting, plasma membrane 1 S homeolog Neighboring gene solute carrier family 23 member 1-like Neighboring gene KIT ligand S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of heart growth IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC495060
Names
MAP kinase phosphatase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094761.2 → NP_001088230.1  uncharacterized protein LOC495060

    See identical proteins and their annotated locations for NP_001088230.1

    Status: PREDICTED

    Source sequence(s)
    BC084215
    UniProtKB/TrEMBL
    A0A974DAQ8, Q5XH58
    Related
    ENSXLAP00005062090.1, ENSXLAT00005063543.1
    Conserved Domains (3) summary
    COG2453
    Location:202 → 354
    CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
    cd00127
    Location:205 → 342
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:20 → 147
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    92643743..92649716
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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