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atp2a2.L ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495046, updated on 4-Nov-2024

Summary

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Official Symbol
atp2a2.L
Official Full Name
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 L homeolog
Primary source
Xenbase:XB-GENE-17337755
Locus tag
XELAEV_18007836mg
See related
EnsemblRapid:ENSXLAG00005035125 AllianceGenome:Xenbase:XB-GENE-17337755
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
dar; atp2b; serca2
Summary
Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See atp2a2.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
21
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (176535444..176566766)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (163377112..163405109)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 81 L homeolog Neighboring gene uncharacterized LOC108716854 Neighboring gene anaphase promoting complex subunit 7 L homeolog Neighboring gene actin related protein 2/3 complex subunit 3 L homeolog Neighboring gene GPN-loop GTPase 3 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like; uncharacterized protein LOC495046

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094749.1 → NP_001088218.1  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like

    See identical proteins and their annotated locations for NP_001088218.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098958
    UniProtKB/TrEMBL
    A0A974I4U1, A0A974I5S7, Q4KLX4
    Related
    ENSXLAP00005105158.1, ENSXLAT00005107203.1
    Conserved Domains (6) summary
    TIGR01116
    Location:53 → 988
    ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase
    pfam00122
    Location:93 → 340
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:783 → 986
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:4 → 72
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12710
    Location:605 → 711
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:419 → 527
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    176535444..176566766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041581899.1 → XP_041437833.1  uncharacterized protein LOC495046 isoform X1

    UniProtKB/TrEMBL
    A0A8J1M864, A0A974I4U1
    Related
    ENSXLAP00005105325.1, ENSXLAT00005107373.1
    Conserved Domains (1) summary
    cd02083
    Location:5 → 988
    P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
Nucleotide Protein Strain
Heading Accession and Version

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