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chga.S chromogranin A S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495018, updated on 4-Nov-2024

Summary

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Official Symbol
chga.S
Official Full Name
chromogranin A S homeolog
Primary source
Xenbase:XB-GENE-960417
Locus tag
XELAEV_18041309mg
See related
EnsemblRapid:ENSXLAG00005009155 AllianceGenome:Xenbase:XB-GENE-960417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
chga
Summary
Predicted to act upstream of or within adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation; defense response to bacterium; and negative regulation of secretion by cell. Predicted to be located in chromaffin granule; extracellular space; and transport vesicle. Is expressed in endocrine system. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypertension; and prostate cancer. Orthologous to human CHGA (chromogranin A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See chga.S in Genome Data Viewer
Location:
chromosome: 8S
Exon count:
10
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8S NC_054386.1 (20751135..20772235, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 8S NC_030739.1 (20663935..20685646, complement)

Chromosome 8S - NC_054386.1Genomic Context describing neighboring genes Neighboring gene MGC84091 protein Neighboring gene inositol-tetrakisphosphate 1-kinase S homeolog Neighboring gene golgin A5 S homeolog Neighboring gene uncharacterized LOC121397718 Neighboring gene legumain S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within defense response to bacterium IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of catecholamine secretion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromaffin granule IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chromogranin A S homeolog
Names
chromogranin A (parathyroid secretory protein 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094724.1 → NP_001088193.1  chromogranin A S homeolog precursor

    See identical proteins and their annotated locations for NP_001088193.1

    Status: PROVISIONAL

    Source sequence(s)
    BC084106
    UniProtKB/TrEMBL
    Q5XHF1
    Related
    ENSXLAP00005026657.1, ENSXLAT00005027389.1
    Conserved Domains (1) summary
    pfam01271
    Location:25 → 323
    Granin; Granin (chromogranin or secretogranin)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    20751135..20772235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018232056.2 → XP_018087545.1  chromogranin A S homeolog isoform X3

    UniProtKB/TrEMBL
    A0A8J0TEX7
    Related
    ENSXLAP00005026681.1, ENSXLAT00005027413.1

  2. XM_018232055.2 → XP_018087544.1  chromogranin A S homeolog isoform X2

    UniProtKB/TrEMBL
    A0A8J0TLC0
    Related
    ENSXLAP00005026687.1, ENSXLAT00005027419.1

  3. XM_018232054.2 → XP_018087543.1  chromogranin A S homeolog isoform X1

    UniProtKB/TrEMBL
    A0A1L8F0E9, A0A974C257
Nucleotide Protein Strain
Heading Accession and Version

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