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smpd4.L sphingomyelin phosphodiesterase 4 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 495009, updated on 4-Nov-2024

Summary

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Official Symbol
smpd4.L
Official Full Name
sphingomyelin phosphodiesterase 4 L homeolog
Primary source
Xenbase:XB-GENE-962471
Locus tag
XELAEV_18007603mg
See related
EnsemblRapid:ENSXLAG00005013237 AllianceGenome:Xenbase:XB-GENE-962471
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
smpd4
Summary
Predicted to enable sphingomyelin phosphodiesterase activity. Predicted to act upstream of or within cellular response to tumor necrosis factor; ceramide biosynthetic process; and sphingomyelin catabolic process. Predicted to be located in endoplasmic reticulum; nuclear envelope; and sarcolemma. Orthologous to human SMPD4 (sphingomyelin phosphodiesterase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See smpd4.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
19
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (165547067..165568154)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (152464226..152485273)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene gamma-glutamyltransferase 1 L homeolog Neighboring gene gamma-glutamyltransferase 5 L homeolog Neighboring gene uncharacterized LOC108716031 Neighboring gene mediator complex subunit 15 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sphingomyelin phosphodiesterase D activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingomyelin phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables sphingomyelin phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to tumor necrosis factor ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within ceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ceramide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within glycerophospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sphingomyelin catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sphingomyelin catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  
located_in sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sphingomyelin phosphodiesterase 4
Names
nSMase-3
nSMase3
neutral sphingomyelinase 3
neutral sphingomyelinase III
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
NP_001088184.1
XP_041437798.1
XP_041437805.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001094715.1 → NP_001088184.1  sphingomyelin phosphodiesterase 4

    See identical proteins and their annotated locations for NP_001088184.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097653
    UniProtKB/TrEMBL
    A0A974I4W3
    Related
    ENSXLAP00005039340.1, ENSXLAT00005040261.1
    Conserved Domains (1) summary
    pfam14724
    Location:9 → 741
    mit_SMPDase; Mitochondrial-associated sphingomyelin phosphodiesterase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    165547067..165568154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041581864.1 → XP_041437798.1  sphingomyelin phosphodiesterase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8J1M830
    Related
    ENSXLAP00005039335.1, ENSXLAT00005040256.1

  2. XM_041581871.1 → XP_041437805.1  sphingomyelin phosphodiesterase 4 isoform X2

    UniProtKB/Swiss-Prot
    Q4V7Y8, Q5XHG1
    UniProtKB/TrEMBL
    A0A8J1M9R9
    Related
    ENSXLAP00005039284.1, ENSXLAT00005040205.1
    Conserved Domains (1) summary
    pfam14724
    Location:9 → 769
    mit_SMPDase; Mitochondrial-associated sphingomyelin phosphodiesterase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XHG1.2 GenPept UniProtKB/Swiss-Prot:Q5XHG1

Gene LinkOut

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