atg4b.L autophagy related 4B, cysteine peptidase L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: atg4b.L
Official Full Name: autophagy related 4B, cysteine peptidase L homeolog
Primary source: Xenbase:XB-GENE-967116
Locus tag: XELAEV_18027812mg
See related: EnsemblRapid:ENSXLAG00005014610 AllianceGenome:Xenbase:XB-GENE-967116
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: apg4b; atg4b
Summary: Predicted to enable cysteine-type peptidase activity and protein-phosphatidylethanolamide deconjugating activity. Predicted to act upstream of or within microautophagy; mitophagy; and otolith mineralization completed early in development. Predicted to be located in several cellular components, including autophagosome; endoplasmic reticulum; and mitochondrion. Orthologous to human ATG4B (autophagy related 4B cysteine peptidase). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 5L

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (134964975..134987326, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (123898892..123921449, complement)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we characterized the Xenopus laevis xAtg4B protease along with two of its substrates, xLC3B and xGATE16. More specifically, we were interested in finding well-behaved and stable protease fragments with optimal proteolytic activity
Title: The Xenopus laevis Atg4B Protease: Insights into Substrate Recognition and Application for Tag Removal from Proteins Expressed in Pro- and Eukaryotic Hosts.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein-phosphatidylethanolamide deconjugating activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autophagy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within microautophagy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitophagy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within otolith mineralization completed early in development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in autophagosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: cysteine protease ATG4B

Names: ATG4 autophagy related 4 homolog B; autophagy-related protein 4 homolog B

NP_001088025.1

EC 3.4.22.-

XP_018117516.1

EC 3.4.22.-

XP_018117517.1

EC 3.4.22.-

XP_018117518.1

EC 3.4.22.-

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001094556.1 → NP_001088025.1 cysteine protease ATG4B

See identical proteins and their annotated locations for NP_001088025.1

Status: PROVISIONAL

Source sequence(s)

BC082660

UniProtKB/Swiss-Prot

Q640G7

UniProtKB/TrEMBL

A0A974CW52

Related

ENSXLAP00005042778.1, ENSXLAT00005043845.1

Conserved Domains (1) summary

pfam03416
Location:40 → 325

Peptidase_C54; Peptidase family C54

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

134964975..134987326 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)